Publication HistoryView all

  • [Show abstract] [Hide abstract]
    ABSTRACT: In people, abnormalities in vertebral column conformation, such as kyphoscoliosis, induce degenerative changes in adjacent intervertebral disc (IVD) structure and composition. It was hypothesised that canine IVDs adjacent to a vertebral malformation undergo early degeneration. In a blinded retrospective study, thoracic IVD degeneration was evaluated in 14 dogs on magnetic resonance images using Pfirrmann’s grade. IVDs adjacent to a vertebral malformation had higher grades of degeneration than non-adjacent IVDs (P<0.0001). There was an age-dependency, with dogs between 1 and 4 years showing higher grade of degeneration in adjacent than non-adjacent IVDs (P<0.0001). Conversely, in older dogs, all IVDs - including the non-adjacents - showed degenerative signs, possibly due to normal aging. These results suggest that congenital vertebral malformation results in early degeneration of adjacent IVDs.
    The Veterinary Journal 06/2014; 200(3). DOI:10.1016/j.tvjl.2014.03.027
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective-To evaluate a modified proportional margins approach to resection of mast cell tumors (MCTs) in dogs. Design-Retrospective case series. Animals-40 dogs with subcutaneous and cutaneous MCTs undergoing curative intent surgery. Procedures-Medical records were searched to identify dogs with a cytologically or histologically confirmed diagnosis of MCT that had not previously been treated surgically and that had undergone full oncological staging. In those dogs, tumors were resected with lateral margins equivalent to the widest measured diameter of the tumor and a minimum depth of 1 well-defined fascial plane deep to the tumor. Surgical margins were evaluated histologically. Cutaneous tumors were graded by use of the Patnaik system and the 2-tier system described by Kiupel et al. The prognosis for subcutaneous tumors was assessed in accordance with published recommendations. Follow-up information on dog health status was obtained through clinical examination, the dog owners, and the referring veterinarians. Results-The 40 dogs had 47 tumors. Forty-one (87%) tumors were cutaneous, and 6 (13%) were subcutaneous. On the basis of the Patnaik system, 21 (51%) cutaneous tumors were considered grade I, 18 (44%) were considered grade II, and 2 (5%) were considered grade III. On the basis of the Kiupel system, 37 (90%) cutaneous tumors were considered low grade, and 4 (10%) were considered high grade. The prognosis for the 6 subcutaneous tumors was classified as likely resulting in a shorter (2) or longer (4) survival time. Forty tumors were deemed to have been excised with clear margins and 7 with incomplete margins. Local recurrence was not recorded for any dog but was suspected for 1 (2%) tumor, although not confirmed. Interval from tumor excision to follow-up ranged from 30 to 1,140 days (median, 420 days). Conclusions and Clinical Relevance-The modified proportional margins system resulted in satisfactory local disease control in dogs with MCTs.
    Journal of the American Veterinary Medical Association 11/2013; 243(10):1436-41. DOI:10.2460/javma.243.10.1436
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cruciate ligaments (CLs) are primary stabilisers of the knee joint and canine cranial cruciate ligament disease (CCLD) and rupture is a common injury. Elastin fibres, composed of an elastin core and fibrillin containing microfibrils, are traditionally considered minor components of the ligament extracellular matrix (ECM). However, their content and distribution in CLs is unknown. The purposes of this study were to determine the elastin content of canine CLs and to ascertain its relationship to other biochemical components and histological architecture. Macroscopically normal CLs were harvested from Greyhounds (n=11), a breed with a low risk of CCLD. Elastin, collagen and sulfated glycosaminoglycan content were measured and histological scoring systems were developed to quantify ECM changes using a modified Vasseur score (mVS) and oxytalan fibre (bundles of microfibrils) staining. Elastin contents were 9.86±3.97% dry weight in the cranial CL and 10.79±4.37% in the caudal CL, respectively, and did not alter with advancing histological degeneration. All CLs demonstrated mild degenerative changes, with an average mVS score of 11.9±3.3 (maximum 24). Increasing degeneration of the ligament ECM showed a positive correlation (r=0.690, P<0.001) with increased oxytalan fibre staining within the ECM. Elastin is an abundant protein in CLs forming a greater proportion of the ligament ECM than previously reported. The appearance of oxytalan fibres in degenerative CL ECM may reflect an adaptive or reparative response to normal or increased loads. This finding is important for future therapeutic or ligament replacement strategies associated with cranial CL injury.
    The Veterinary Journal 11/2013; 199(1). DOI:10.1016/j.tvjl.2013.11.002

  • The Veterinary Journal 10/2013; 199(1). DOI:10.1016/j.tvjl.2013.10.026
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective: To compare the efficacy of meloxicam and a glucosamine-chondroitin (Glu-Ch) supplement in the management of feline osteoarthritis (OA). Methods: Prospective, blinded, randomized clinical trial. Cats over eight years of age with clinical signs of chronic OA were assigned to one of two groups and Glu-Ch or meloxicam was administered orally for 70 days, followed by a placebo until day 98. Cats were assessed by a veterinarian on five occasions and the owner completed an assessment form at the same time. Results: Data were collected from thirty cats. Pre-treatment disease scores were significantly higher in the meloxicam group for owner mobility (p=0.01) and veterinary lameness (p=0.02). Owner mobility scores at day 14 (p=0.01) and day 42 (p=0.002) were significantly improved compared to pre-treatment scores for the meloxicam group. When meloxicam and Glu-Ch were discontinued and the placebo commenced, a significant proportion of the meloxicam group showed worsening of all the owner-assessed scores between day 70 and day 98, when compared to the Glu-Ch group (mobility p=0.01; activity p=0.02; temperament p=0.04; lifestyle p=0.01). Conclusions: Treatment with meloxicam resulted in a significant improvement in mobility and activity levels of cats with OA until the placebo was introduced. A greater proportion of cats receiving meloxicam medication showed a significant worsening of owner assessment scores once the placed was introduced, when compared to the Glu-Ch group.
    Veterinary and Comparative Orthopaedics and Traumatology 10/2013; 27(1). DOI:10.3415/VCOT-12-11-0139
  • [Show abstract] [Hide abstract]
    ABSTRACT: To assess whether obesity has any association with objectively measured physical activity levels in dogs. Thirty-nine dogs wore Actigraph GT3X accelerometers (Actigraph) for 7 consecutive days. Each dog was classified as ideal weight, overweight or obese using the 5-point body condition scoring system. Total volume of physical activity and time spent in sedentary behaviour, light-moderate intensity physical activity and vigorous intensity physical activity were compared between body condition categories. Valid accelerometry data were returned for 35 of 39 dogs recruited. Eighteen dogs were classed as ideal weight, 9 as overweight and the remaining 8 as obese. All dogs spent a significant proportion of the day sedentary and obese dogs spent significantly less time in vigorous intensity physical activity than ideal weight dogs (7 ±3 minute/day versus 21 ±15 minute/day, P=0·01). Obesity is associated with lower vigorous intensity physical activity in dogs, as is also thought to occur in humans. These preliminary findings will help inform a future, larger study and may also improve our understanding of the associations between obesity and physical activity in dogs.
    Journal of Small Animal Practice 10/2013; 54(11). DOI:10.1111/jsap.12142
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cystic lesions affecting the vertebral canal or spinal cord have rarely been reported in cats. A 3-year-old female neutered domestic longhair cat presented for evaluation of a 2-year-history of episodes of ataxia and paresis affecting all limbs. Neurological examination was consistent with a lesion in the C1-C5 spinal cord segments. Magnetic resonance imaging (MRI) showed a fluid-filled lesion at the occipito-atlanto-axial region causing dynamic spinal cord compression on flexion of the neck. The imaging characteristics were compatible with a juxta-articular cyst. To our knowledge, this is the first report of a fluid-filled lesion causing dynamic cervical spinal cord compression in a cat and highlights the importance of performing flexion-extension MRI views in diagnosing cases with dynamic spinal cord compression.
    10/2013; 16(6). DOI:10.1177/1098612X13507073

  • 10/2013; 173(13):323-324. DOI:10.1136/vr.f5918

  • 10/2013; 173(13):314-315. DOI:10.1136/vr.f5851
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cavernous sinus syndrome is characterised by internal and external ophthalmoplegia and sensory deficits over the head due to combined deficits of the three cranial nerves (CNs) responsible for the eye movements and pupil function (CN III, IV, VI) and at least one branch of the trigeminal nerve (CN V). It has rarely been described in cats and may occur secondary to inflammatory, infectious or neoplastic lesions within the region of the cavernous sinus on the ventral aspect of the calvarium. This report describes the clinical and magnetic resonance imaging findings in a 14-year-old domestic shorthair cat with neurological deficits compatible with cavernous sinus syndrome caused by presumptive extranodal lymphoma. Treatment with chemotherapy resulted in clinical and imaging remission. Identification of the neurological deficits in cavernous sinus syndrome allows accurate neuroanatomical localisation in order to target diagnostic imaging studies.
    09/2013; 16(6). DOI:10.1177/1098612X13505580
Information provided on this web page is aggregated encyclopedic and bibliographical information relating to the named institution. Information provided is not approved by the institution itself. The institution’s logo (and/or other graphical identification, such as a coat of arms) is used only to identify the institution in a nominal way. Under certain jurisdictions it may be property of the institution.
View all

Top publications last week by reads

The Veterinary record 07/2002; 150(26):799-804. DOI:10.1136/vr.150.26.799
19 Reads
Journal of Small Animal Practice 10/2008; 49(9):488. DOI:10.1111/j.1748-5827.2008.00601.x
12 Reads