Bath, Somerset, United Kingdom

Departments View all

Department of Mechanical Engineering
1,047
Total Impact Points
186
Members
Department of Biology and Biochemistry
7,650
Total Impact Points
178
Members
Faculty of Management
3
Total Impact Points
172
Members

Publication History View all

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs (eRNAs) induced in human monocytic THP1 cells following activation of the innate immune response in response to lipopolysaccharide (LPS). Specifically, we have demonstrated that LPS-induced expression of individual eRNAs is mediated through divergent intracellular signalling pathways that includes NF-κB and the mitogen activated protein kinases, extracellular regulated kinase-1/2 and p38. Copyright © 2014. Published by Elsevier B.V.
    FEBS Letters 12/2014; 589(3). DOI:10.1016/j.febslet.2014.12.026
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The knowledge structures and reasoning processes that underlie the use of external representations (ERs) in individuals with autism spectrum disorder (ASD) are not well understood. This paper compares the organisation of knowledge of ERs in young people with a diagnosis of ASD and an age-matched typically developing control group. ASD and non-ASD participants (twenty-eight in each group) were given an untimed ER card-sorting task. The ERs were based on representations used in educational software, for example graphs, charts, and text. Cluster analysis of the card sort task revealed similar clusters for both groups: maps, drawings, text, graphs and charts, and network and tree diagrams. However, comparison of the card sorts of the two different groups showed a difference in 'basic level' categories. While in the non-ASD group, maps and non-maps were the most distinctive category, analysis of the ASD cluster revealed, in addition, another 'basic level' category of textual representations. These results are discussed in relation to theories of information processing in autism. Our ultimate research aim is to develop educational software tailored to the specific needs of users with ASD. We wish to use our research results to inform requirements for the development of such educational software, in which ERs are able to support differences in information processing for individuals with ASD.
  • Source
    Algae for Renewable Energy; 11/2014

Information

  • Address
    Claverton Down, BA2 7AY, Bath, Somerset, United Kingdom
  • Website
    http://www.bath.ac.uk/
Information provided on this web page is aggregated encyclopedic and bibliographical information relating to the named institution. Information provided is not approved by the institution itself. The institution’s logo (and/or other graphical identification, such as a coat of arms) is used only to identify the institution in a nominal way. Under certain jurisdictions it may be property of the institution.

1992 Members View all

Top Collaborating Institutions

Collaborations

This map visualizes which other institutions researchers from University of Bath have collaborated with.

Rg score distribution

See how the RG Scores of researchers from University of Bath are distributed.