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ABSTRACT: Placebo and nocebo effects have recently emerged as an interesting model to understand some of the intricate underpinnings of the mind-body interaction. A variety of psychological mechanisms, such as expectation, conditioning, anxiety modulation, and reward, have been identified, and a number of neurochemical networks have been characterized across different conditions, such as pain and motor disorders. What has emerged from the recent insights into the neurobiology of placebo and nocebo effects is that the psychosocial context around the patient and the therapy, which represents the ritual of the therapeutic act, may change the biochemistry and the neuronal circuitry of the patient's brain. Furthermore, the mechanisms activated by placebos and nocebos have been found to be the same as those activated by drugs, which suggests a cognitive/affective interference with drug action. Overall, these findings highlight the important role of therapeutic rituals in the overall therapeutic outcome, including hypnosis, which may have profound implications both in routine medical practice and in the clinical trials setting.The American journal of clinical hypnosis 01/2015; 57(3):267-284. DOI:10.1080/00029157.2014.976785
Conference Paper: Graphing motion to understand math with children.[Show abstract] [Hide abstract]
ABSTRACT: This research study considers the activity of seven year-old children who move in front of a motion detector and then are asked to interpret the shape of the graphs of their motions. Many other activities follow, in which children have: to discuss on how to move for changing the shape of a graph; to get given graphs by moving in the right way; to tell stories about motions, to mime them and to represent them using graphs; to associate animals, vehicles and cartoons characters to given graphs. All these activities were filmed using two video-cameras and analysed. Our purpose is not to identify cognitive structures, but to gain insight into how situations involving body motion and symbols (graphs, in this case) look to – and are experienced by – very young pupils. To this aim, attention is paid to the way children construct meaning for the notion of change making sense of the shape of the graphs in relation to their movements. We study children's words, gestures, drawings and sketches to look at this meaning-making process.CIEAEM 59; 12/2014
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ABSTRACT: The equal partitioning of cell mass between daughters is the usual and expected outcome of cytokinesis for self-renewing cells. However, most studies of partitioning during cell division have focused on daughter cell shape symmetry or segregation of chromosomes. Here, we use live cell interferometry (LCI) to quantify the partitioning of daughter cell mass during and following cytokinesis. We use adherent and non-adherent mouse fibroblast and mouse and human lymphocyte cell lines as models and show that, on average, mass asymmetries present at the time of cleavage furrow formation persist through cytokinesis. The addition of multiple cytoskeleton-disrupting agents leads to increased asymmetry in mass partitioning which suggests the absence of active mass partitioning mechanisms after cleavage furrow positioning.PLoS ONE 12/2014; 9(12):e115726. DOI:10.1371/journal.pone.0115726
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