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ABSTRACT: The paper gives an overall description of the breaking-wave celerity on the basis of a wave-by-wave analysis that has been performed by using field data collected during the ECORS Project (Truc Vert Beach, France, 2008). Data coming from two pressure sensors have been analyzed with the aim to correlate, after a zero-crossing analysis, each wave of both signals. The method is based on a first correlation between 10′ time windows of both signals and, then, on the individuation of the correct time lag for each wave. Such data, which reveals a quasi-gaussian behavior of the breaking wave celerity, have also been used to relate the wave celerity with suitable wave characteristics, and comparisons are made with the most common formulas that can be found in the literature. The wave-by-wave method, validated by means of suitable laboratory test data, gives good results in the evaluation of the celerity, especially when it is made to depend on both a velocity scale and the wave non-linearity parameter. Further, a comparison with literature models used for the prediction of breaking wave celerity suggests good performances of both solitary-wave (correlation coefficient R^2 = 0.79) and shock-wave (R^2 = 0.71) theories, that give results well matched to the field data.
Applied Ocean Research 06/2014; 46:15–27.
Burns: journal of the International Society for Burn Injuries 02/2014;
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ABSTRACT: There is growing interest in osteoinductive agents for fracture healing especially in patients with non-union or delayed-union fractures. The aim of the present study is the assessment of the association of Vitamins D3 and K1 on proliferation and differentiation of human mesenchymal stem cells (hMSCs) derived from fracture sites in view of a possible clinical use. The synergic effect of Vitamin D3 and Vitamin K2 in preventing osteoporosis has been documented in clinical practice; however no reports investigating this association for fracture healing are present. Our data show a different outcome on cell proliferation linked to the different timing of drug administration as well as a synergic effect of the two vitamins on cell differentiation. The high level of osteocalcin and carboxylated osteocalcin detected in hMSCs treated with the association of the two vitamins in comparison with controls and with single vitamin administration underline the differentiation of these cells into osteoblastic phenotype. Our results indicate for the first time that vitamin D3 and K1 association is able to modulate in vitro the differentiation towards osteoblastic phenotype of hMSCs derived from fracture sites, thus offering clinicians a promising and low-cost strategy for reparative osteogenesis.
Journal of biological regulators and homeostatic agents 01/2014; 22(1):35-44.
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