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    ABSTRACT: Chrysin (5,7-dihydroxyflavone) is a flavonoid, natural component of traditional medicinal herbs, present in honey, propolis and many plant extracts. The objective of this study was to investigate the hypolipidemic properties of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice. Triton WR-1339 was administered intraperitoneally (400 mg/kg) to overnight-fasted mice to develop acute hyperlipidemia. Chrysin was administered orally (10 mg/kg) 30 min before Triton WR-1339. At 24 h after Triton WR-1339 injection, blood samples were collected to measure plasma lipid levels. The hepatic thiobarbituric acid reactive substances (TBARS), carbonyl content, non-protein sulfhydryl (NPSH) and ascorbic acid (AA) levels, as well as catalase (CAT) and superoxide dismutase (SOD) activity were recorded. Chrysin administration significantly decreased total cholesterol levels. In addition, it partially decreased non-high density lipoprotein-cholesterol and triglycerides levels in plasma of hyperlipidaemic mice. In addition chrysin administration prevented the increase on TBARS levels and prevented the decrease in SOD activity induced by Triton WR-1339. These findings indicated that chrysin was able to decrease plasma lipids concentration and that its antioxidant properties was, at least in part, involved in the hypolipidaemic action of chrysin.
    Toxicology Reports 12/2014; 1. DOI:10.1016/j.toxrep.2014.02.003
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    ABSTRACT: Objective Changing gait speed is a common strategy to manipulate exercise intensity during physical exercise, but may elicit higher impact forces and consequent joint loading. Here we analyzed the effects of increasing walking velocity on plantar pressure and asymmetries in elderly with knee osteoarthritis (OA). Our hypothesis was that the contralateral limb could receive higher loading compared to the OA limb in the different walking speeds tested. Methods Twelve elderly with unilateral knee OA walked at different self‐selected speeds along a 10 m pass way stepping on an instrumented mat for measurement of plantar pressure at preferred, slow and fast gait speeds. Five steps were recorded for each speed. Plantar pressure data were compared between the speeds and legs. Results speeds were significantly different between them (p < 0.05). Mean and peak plantar pressure increased when speed changed from slow to fast (p < 0.05). Velocity of the center of pressure increased and the single stance time decreased when walk speed was increased (p < 0.05). Any asymmetries were observed. Conclusion Increasing gait speed from slow to fast in subjects with unilateral knee OA significantly affected variables of plantar pressure, but asymmetries between committed and contralateral leg were not detected.
    Revista Brasileira de Reumatologia 11/2014; 54(6). DOI:10.1016/j.rbr.2014.06.004
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    ABSTRACT: Objetivo identificar a prevalência de dor lombar inespecífica e os fatores associados em adolescentes de Uruguaiana/RS. Métodos estudo transversal de base escolar, feito com adolescentes de 10 a 17 anos matriculados no turno diurno das redes municipal e estadual de ensino de Uruguaiana/RS. Foram avaliados 1.455 adolescentes. O procedimento de coleta dos dados ocorreu em duas etapas. Inicialmente foi aplicado um questionário sobre indicadores sociodemográficos, comportamentos e hábitos da rotina diária e histórico de dor lombar inespecífica. Posteriormente foram avaliadas as medidas de estatura, massa corporal, flexibilidade e força/resistência abdominal. Para a análise dos dados foram usados os métodos univariado, bivariado e multivariável e foi considerado nível de significância de 5% para todos os testes. Resultados a prevalência de dor lombar nos adolescentes avaliados foi de 16,1%. Por sexo, o masculino apresentou uma prevalência de 10,5% e o feminino, de 21,6%. As variáveis sexo, índice de massa corporal, força/resistência abdominal e nível de atividade física apresentaram associação estatisticamente significativa com a dor lombar inespecífica. Na análise ajustada o sexo (OR = 2,36; p < 0,001), a idade (OR = 1,14; p < 0,001) e o índice de massa corporal (OR = 1,44; p = 0,029) mantiveram significância no modelo final. Conclusões adolescentes do sexo feminino que apresentaram idades mais elevadas e estavam com sobrepeso ou obesidade têm mais chances de desenvolver dor lombar inespecífica.
    11/2014; 49(6). DOI:10.1016/j.rboe.2014.10.003


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