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ABSTRACT: The lack of reading skills affects the way users search on the Web or interact with computer interfaces. Developers and designers must comprehend these users’ limitations in order to provide features that meet their needs and help them to have a better experience on the Web when using search features. In this work we analyzed the interaction of users with low reading skills with a limited set of search features. Their behavior and preferences were compared to general users’ behavior on search interfaces retrieved from literature. These comparison permitted to identify related issues and create a set of common recommendations.Procedia Computer Science 01/2014; 27:334–342. DOI:10.1016/j.procs.2014.02.037
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ABSTRACT: Retinoblastoma (RB) is a malignant neoplasia that occurs mostly in children under five years. Recently, CDKN1A gene has been shown to be up-regulated in a context of loss of function of pRb. This gene encodes the p21 protein, which is the bona fide effector of p53. We hypothesized whether two putatively functional single nucleotide polymorphisms (SNPs) of CDKN1A (rs1801270 C>A and rs1059234 C>T) may influence the risk and/or survival of RB patients. We genotyped both SNPs in 141 RB patients and 120 unrelated healthy individuals. Statistical analyses consisted of chi-square (x(2)), odds ratio (OR) and survival curves by Kaplan-Meier (KM) method. We found that patients who carry the genotype CA for rs1801270 and CT for rs1059234 were associated to an increased risk of RB (OR= 2.5, 95%CI= 1.38 - 4.53) whereas patients with CC for both polymorphisms were associated to a lower risk of developing RB (OR= 0.43, 95%CI = 0.25 - 0.74). On the other hand, KM curves did not show statistically significant differences in survival among the studied polymorphisms. We conclude that the minor alleles of rs1801270 and rs1059234 polymorphisms may act as risk factors for the development of retinoblastoma in our sample.Carcinogenesis 09/2013; DOI:10.1093/carcin/bgt308
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ABSTRACT: Intrathecal synthesis of human T-lymphotropic virus type 1 (HTLV-1) antibodies (Abs) represents conclusive evidence of a specific immune response in the central nervous system of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. Western blotting (WB) for HTLV Abs in serum is a confirmatory test for HTLV-1 infection. The aim of this study was to standardise the Western blot to demonstrate the intrathecal pattern of Abs against HTLV-1 proteins in HAM/TSP patients. Paired cerebrospinal fluid (CSF) and serum samples were selected from 20 patients with definite HAM/TSP, 19 HTLV-1 seronegative patients and two HTLV-1 patients without definite HAM/TSP. The presence of reactive bands of greater intensity in the CSF compared to serum (or bands in only the CSF) indicated the intrathecal synthesis of anti-HTLV-1 Abs. All definite HAM/TSP patients presented with an intrathecal synthesis of anti-HTLV-1 Abs; these Abs were not detected in the control patients. The most frequent intrathecal targets of anti-HTLV-1 Abs were GD21, rgp46-I and p24 and, to a lesser extent, p19, p26, p28, p32, p36, p53 gp21 and gp46. The intrathecal immune response against env (GD21 and rgp46-I) and gag (p24) proteins represents the most important humoral pattern in HAM/TSP. This response may be used as a diagnostic marker, considering the frequent association of intrathecal anti-HTLV-1 Ab synthesis with HAM/TSP and the pathogenesis of this neurological disease.Memórias do Instituto Oswaldo Cruz 09/2013; 108(6):730-4. DOI:10.1590/0074-0276108062013009
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Rg score distribution
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