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ABSTRACT: To study the anti-inflammatory actions of electroacupuncture (EAc) on an experimental colitis model in mice. Thirty-eight male Swiss mice, divided in five groups, were subjected to induction of colitis by TNBS in 50% ethanol. Saline (SAL) and ethanol (ETNL) groups served as controls. TNBS+EAc and TNBS+ dexamethasone subgroups were treated with EAc 100Hz and dexamethasone (DEXA) 1 mg/Kg/day, respectively. After three days, a colon segment was obtained for quantification of myeloperoxidase (MPO) activity, immunohistochemistry for iNOS, malondialdehyde (MDA) and cytokines (IL-1β and IL-10). Neutrophilic activity, assayed as MPO activity, was significantly higher in the TNBS colitis group than that in the saline control group. TNBS+EAc group showed suppression of IL-10 in the colon. EAc treatment significantly reduced the concentration of MDA and the expression of iNOS, as compared to the other groups. Electroacupuncture 100Hz applied to acupoint ST-36 promotes an anti-inflammatory action on the TNBS-induced colitis, mediated by increase of IL-10 and decrease of iNOS expression.Acta cirurgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia 12/2014; 29(12):787-93. DOI:10.1590/S0102-86502014001900004
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ABSTRACT: We evaluated the neuropharmacological profile of acetylated alpha-and beta-amyrin (AcAMY) obtained by the acetylation of the isomeric mixture of alpha-and beta-amyrin isolated from Protium heptaphyllum. Male Swiss mice were administered with AcAMY (2.5, 5, 10 and 25 mg/kg, i.p.), and anticonvulsant (pentylenetrazole-and pilocarpine-induced convulsions), sedative (barbiturate-induced sleep and open field tests) and anxiolytic (elevated plus maze test) activities were studied. Results showed that AcAMY administered intraperitoneally or orally, protected the animals against penty-lenetetrazole-but not against pilocarpine-induced convulsions. The drug increased both the latency to the 1 st convulsion and the latency to death. The barbiturate-induced sleeping time was also increased, as well as the ethyl ether-induced sleeping time, confirming the sedative nature of AcAMY. The acute administration of AcAMY also produced an anx-iolytic effect. After the sub-chronic administration, both sedative and anxiolytic effects were manifested, at the two higher doses. Amino acids measurements in brain areas of mice treated with AcAMY (25 mg/kg, i.p., for 7 days) showed an 89% increase in tyrosine levels, in the hippocampus. In the striatum, tyrosine and taurine were increased by 97 and 79%, re-spectively, while decreases in the levels of aspartate, GABA and glutamate of 72, 55 and 60%, respectively were ob-served. In conclusion, our results showed that AcAMY presents sedative, anxiolytic and anticonvulsant properties. Al-though the drug mechanism of action is not completely clarified, it seems to involve a decrease in excitatory amino acids and an increase of inhibitory amino acids. Furthermore, the GABAergic system may also play a role.The Open Pharmacology Journal 11/2014; DOI:10.2174/1874143600903010009
Conference Paper: PERDAS NAS OPERAÇÕES PRÉ-ABATE: ÊNFASE EM ESPERA[Show abstract] [Hide abstract]
ABSTRACT: Introdução Dentre as poucas informações existentes sobre as operações pré-abate, sabe-se que muitos são os fatores que contribuem com o estresse das aves durante estas etapas e que a intensidade destes efeitos determina o nível elevado de perdas por mortalidade na chegada ("Death on arrival" – DOA). No entanto, a busca pela localização destes pontos críticos tornou-se um dos principais desafios da cadeia produtiva de frangos de corte, com o objetivo de reduzir as perdas nesta fase, e consequentemente aumentar a lucratividade para todos os atores envolvidos no cenário avícola. Destaca-se nesta abordagem a operação de espera nos abatedouros, que consiste no momento em que as aves aguardam na carga o momento de abate. Esta etapa é uma das mais importantes e decisivas quanto ao sucesso obtido entre a retirada das aves das granjas e sua chegada à linha de abate, dentro de condições que facilitem a comercialização de um produto final de qualidade superior. Todavia, mesmo com todos os cuidados tomados nas etapas de pega, carregamento e transporte, estes podem ser perdidos em poucas horas durante a espera, caso esta seja mal planejada para o objetivo de oferecer um ambiente térmico adequado para os animais. Pouco se sabe das condições ideais que possam contribuir para a redução da carga de estresse do animal, proveniente das etapas anteriores.AVESUI'09; 09/2014
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