Universidad de Navarra

Pamplona, Navarra, Spain

Departments View all

Department of Nutrition, Food Science and Physiology
629
Total Impact Points
37
Members
Division of Gene Therapy and Hepatology
991
Total Impact Points
34
Members
Department of Pharmacy and Pharmaceutical Technology
787
Total Impact Points
28
Members

Publication History View all

  • Source
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    ABSTRACT: This investigation deals with the thermal performance of two passive solar components. An attached sunspace with horizontal heat storage and another one with vertical thermal storage were designed in order to optimize the use of solar gain, its storage and distribution in an industrialized component. These sunspaces have been tested under real conditions, comparing their thermal performance with two commonly used components in residential buildings in Spain: a window and a double window making up an attached sunspace. Different series of experimental measurements were made in two test-cells exposed to outdoor conditions in Pamplona (Northern Spain). As a result, nine scenarios during winter 2011 and six ones during summer 2012 have been carried out, comparing all the prototypes two by two with different use modes. Results show that a sunspace with heat storage takes advantage of the solar energy and improves the indoor thermal performance of the adjacent room during winter in a better way than a window or a simple sunspace, and that it has also a better performance in summer. The best results in winter and summer were obtained when an appropriate use of the component is performed, in concordance with outdoor conditions; some thermal control actions for the good performance of these components are suggested.
    Energy and Buildings 09/2014; 80:231–246.
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    ABSTRACT: The interactions of diflunisal (DF) with chitosans (CS) of different molecular weights and carboxymethylchitosan (CMCS), a water-soluble derivative, have been investigated. The interactions in solution have been studied by solubility assays in which the highest solubilisation (13-fold) was obtained with CMCS. Solid dispersions were prepared by coevaporation and kneading methods. Solid state characterisation was performed by X-ray diffraction analysis, scanning electron microscopy, thermomicroscopy, differential thermal analysis and infrared spectroscopy. Drug-polymer electrostatic interactions and hydrogen bonds are the main binding forces in these systems. The kneading method gave rise to amorphous systems regardless of the polymer employed. However, coevaporation resulted in the formation of different polymorphs of diflunisal (form II or III) depending on the type of polymer used. Therefore, it seems that drug-polymer interactions determine the crystallization pattern of the drug. Finally, diflunisal release from these systems improved markedly with CMCS and significantly in the presence of low molecular weight CS.
    International Journal of Pharmaceutics 03/2014;
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    ABSTRACT: Water environments play an important role in the dissemination of antibiotic-resistant bacteria among humans, animals and agricultural sources. In order to assess the spread of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, we analyzed 279 effluent samples from 21 wastewater treatment plants in Navarra (northern Spain). A total of 185 cefpodoxime-resistant bacteria were isolated on ChromID ESBL agar plates, with high predominance of Escherichia coli among isolated species (73%). ESBL production was determined by different methods, concluding its presence in 86.5% of the isolates by the combination disk test, 75.7% by double-disk synergy test and 73.5% by MicroScan(®) NM37 automated system. PCR and sequencing analysis showed that the predominant β-lactamases (bla) genes were blaCTx-M (67.4%) followed by blaTEM (47%), blaSHV (17.4%) and blaOxA (8.3%); furthermore, two or more β-lactamases genes were found in 34.9% of the isolates. The results demonstrate the high prevalence of ESBL-producing Enterobacteriaceae in effluent water from wastewater treatment plants and confirm the need to optimize current disinfection procedures and to improve management of wastewater in an effort to minimize reservoirs of resistant bacteria. Further studies are needed for examining the presence of these bacteria in other environments and for determining the potential dissemination routes of these resistances as well as their impact on human health.
    Water Research 03/2014; 56C:37-47.

Information

  • Address
    Pio XII, 53, 31008, Pamplona, Navarra, Spain
  • Head of Institution
    D. Alfonso Sánchez-Tabernero
  • Website
    http://www.unav.edu
  • Phone
    +34 948425600
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967 Members View all

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Top publications last week by downloads

 
Medicina Clínica. 01/2001; 117(10).
192 Downloads
 
Angiología, ISSN 0003-3170, Vol. 57, Nº. 2, 2005, pags. 119-207. 01/2005;
125 Downloads

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