Valencia, Estado Carabobo, Venezuela

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Department of Physics (FACYT)
17
Total Impact Points
19
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    ABSTRACT: A wide range of Pharmaceuticals and Personal Care Products (PPCPs) are present in the environment, and many of their adverse effects are unknown. The emergence of new compounds or changes in regulations have led to dynamical studies of occurrence, impact and treatment, which consider geographical areas and trends in consumption and innovation in the pharmaceutical industry. A Quantitative study of Structure-Activity Relationship ((Q)SAR) was performed to assess the possible adverse effects of ninety six PPCPs and metabolites with negligible experimental data and establish a ranking of concern, which was supported by the EPA EPI Suite™ interface. The environmental and toxicological indexes, the persistence (P), the bioaccumulation (B), the toxicity (T) (extensive) and the occurrence in Spanish aquatic environments (O) (intensive) were evaluated. The most hazardous characteristics in the largest number of compounds were generated by the P index, followed by the T and B indexes. A high number of metabolites has a concern score equal to or greater than their parent compounds. Three PBT and OPBT rankings of concern were proposed using the total and partial ranking method (supported by a Hasse diagram) by the Decision Analysis by Ranking Techniques (DART) tool, which was recently recommended by the European Commission. An analysis of the sensibility of the relative weights of these indexes has been conducted. Hormones, antidepressants (and their metabolites), blood lipid regulators and all of the personal care products considered in this study were at the highest levels of risk according to the PBT and OPBT total rankings. Furthermore, when the OPBT partial ranking was performed, X-ray contrast media, H2 blockers and some antibiotics were included at the highest level of concern. It is important to improve and incorporate useful indexes for the predicted environmental impact of PPCPs and metabolites and thus focus experimental analysis on the compounds that require urgent attention.
    Journal of Environmental Management 08/2013; 129C:384-397.
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    ABSTRACT: Abstract Levothyroxine (T4) has a well-known effect on the central nervous system (CNS). This effect requires hours of latency by genetic pathway. We tested for short latency nongenomic effects of T4 superfusion on the spinal dorsal horn (DH) evaluating lumbar somatosensory evoked potentials in rats. T4 increased N and P wave amplitudes and N wave area under the curve, but reduced P wave duration and N-P interval, suggesting that T4 exerts both excitatory and synchronizing effects on DH interneurons in less than 300 s, thus, providing evidence of nongenomic effects of T4 on DH.
    Somatosensory & Motor Research 08/2013;
  • Source
    The American journal of tropical medicine and hygiene 08/2013; 89(2):198-201.

Information

  • Address
    Barbula, Valencia, Estado Carabobo, Venezuela
  • Website
    www.uc.edu.ve
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Top publications last week by downloads

 
Alfa Impresiones C.A. edited by Direccion de Medios y Publicaciones Universidad de Carbobo, 04/2012; Universidad de Carabobo Biblioteca de Ciencias y Tecnologia. ISBN: 978-980-233-...
86 Downloads
 
09/2011; Editorial Académica Española. ISBN: 978-3-8473-6618-8
33 Downloads

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