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Centro de Biociencias
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    ABSTRACT: In this work, we study whether aqueous extracts from the roots of Mimosa albida Humb. & Bonpl. ex Willd, a plant known in the Highlands of Chiapas, Mexico as "Lot´om ch´ix are endowed with both antinociceptive and anxiolytic effects. ICR mice were systemically treated with aqueous extracts from Mimosa albida and the reference compounds (diazepam, dipyrone and/or fentanyl) and their behavior was evaluated in several behavioral tests. Administration of aqueous extracts from the roots of Mimosa albida resulted in a reduction of the nociception elicited in mice by both the hot plate (12.5, 25 and 50mg/kg; i.p.) and the acetic acid-induced writhing (25 and 50mg/kg; i.p.) tests. No effects were however observed both in the elevated plus-maze and hole board test (3.2, 12.5 and 25mg/kg; i.p.). In contrast, both locomotion (open field test) and motor coordination (rotarod test) were affected at doses (50, 100 y 200mg/kg; i.p) higher than those having antinociceptive effects. These data suggest that in mice the systemic administration of low doses of aqueous extracts from the roots of Mimosa albida results in antinociceptive effects in several models of pain through mechanisms that not involve the opioid system pathway. These results support the ethnopharmacological use of Mimosa albida in popular medicine.
    Journal of ethnopharmacology 07/2013; 149(2). DOI:10.1016/j.jep.2013.07.010
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    ABSTRACT: Diabetes mellitus type 2 (DM2) is the leading cause of death in people from 15 to 64 years in Mexico, and other regions in the world. For the chronic nature of diabetes and complications caused by inadequate metabolic control, patients may have mood disorders such as depression. Several studies have demonstrated higher prevalence of depression in diabetic patients than in general population. Our objective: is to determine prevalence and factors associated with depressive disorder in patients with type 2 diabetes mellitus enrolled in DiabetIMSS during 2010. Analytical study with random probability sampling. The analysis included prevalence, odds ratios with 95% confidence intervals. The Center Epidemiological Studies Depression Instrument was used. Prevalence of depression was 32.7% at 95% CI = 26.4-38.9%), 67.3% for women, 32.7 % for men; good metabolic control was 51.9%, CI = 95% (45.13-58.66%). We found a higher prevalence of depressive disorders than in the general population, no statistical association with glycemic control, keeping a greater proportion of women as well as the main aspect of depression associated with the perception of emotional support. We discuss DiabetIMSS program effectiveness.
    Revista medica del Instituto Mexicano del Seguro Social 04/2013; 51(1):80-5.
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    ABSTRACT: Objective: to determine the impact of lipid serum abnormalities and the prevalence of metabolic syndrome (MS) in healthy adults. Methods: a cross-sectional, prospective and observational study in apparently healthy adults aged 20 to 60 years who had at least three of the following criteria: abdominal obesity (waist circumference > 102 cm in men and > 88 cm in women), triglycerides ≥ 150 mg/dL, HDL cholesterol < 40 mg/dL in men and < 50 mg/dL in women, blood pressure ≥ 130/85 mmHg and fasting glucose ≥ 110 mg/dL). Results: the prevalence of MS was 20 %, being higher in women (67.7 %) than men (32.3 %). However, no dependence was found with gender (χ(2)= 2.059, p = 0.151). The age range with a higher prevalence of was 45-49 years. Low HDL cholesterol [HR = 11,059 (3.559, 34.610) p < 0.01], was present in 67.9 % of women and hypertriglyceridemia [HR = 15.53 (4.975, 48.513) p < 0.01] was present in 60.5 % of men. Conclusions: the results suggested that hypertriglyceridemia and hypoalphalipoproteinemia are high impact factors for MS in adults.
    Revista medica del Instituto Mexicano del Seguro Social 11/2012; 50(3):301-6.


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