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    ABSTRACT: Pharmacokinetic drug-drug interactions (in particular at metabolism) may result in fatal adverse effects in some cases. This basic information, therefore, is needed for drug therapy even in veterinary medicine; as multidrug therapy is not rare in canines and felines. The aim of this review was focused on possible drug-drug interactions in dogs and cats. The interaction includes enzyme induction by phenobarbital, enzyme inhibition by ketoconazole and fluoroquinolones, and down-regulation of enzymes by dexamethasone. A final conclusion based upon the available literatures and author’s experience is given at the end of the review.
    Journal of Advanced Research 02/2015; 58(3). DOI:10.1016/j.jare.2015.02.003
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    ABSTRACT: Ceria-supported chromium, molybdenum, and tungsten catalysts were prepared by impregnation. The prepared catalysts were characterized using N-2 adsorption, X-ray diffraction (XRD), the temperature-programmed reduction (H-2-TPR), and X-ray photoelectron spectroscopy (XPS) measurements. The catalytic activity in CO hydrogenation was evaluated using a fixed-bed pressurized flow reaction system under the following conditions: 260-300 degrees C, 5.0 MPa, GHSV of 5000 h(-1), and a H-2/CO ratio of 1.0-2.0. The effects of ceria support, group VI metals, and catalyst activation methods on C2+ alcohol synthesis were investigated. The use of ceria supports resulted in a decrease in the selectivity for CO2, and in increases in the selectivity for C2+ alcohols and CO conversion. The selectivity for alcohols on the Mo-based catalysts was higher than those on the corresponding Cr or W-based catalysts. A comparison of the methods of activation for the K(055)Co(06)20MoCe catalyst demonstrated that sulfidation produced the highest CO conversion and selectivity for C2+ alcohols, as well as the lowest, hydrocarbon selectivity. XPS and H-2-TPR measurements show that the mixed metal sulfide phases, e.g., the Co-Mo-S phase, and the thiol group on the catalysts enhanced the formation of C2+ alcohols.
    Fuel Processing Technology 09/2014; 125:86–93. DOI:10.1016/j.fuproc.2014.03.033
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    ABSTRACT: Abstract 1. Growing chickens decrease their voluntary food intake when they receive a diet deficient in a single essential amino acid. Our previous studies suggest that the decreased food intake was associated with some metabolic changes. 2. In order to reveal the involvement of plasma lysine fluctuations in the reduction of food intake, we examined if maintaining the plasma lysine concentration of chickens on a lysine-free diet (the purified diet contained no lysine) restore the food intake to that of the control (lysine hydrochloride 11.9 g/kg) group. 3. Male egg-type chickens at 21 d of age were injected with the lysine at doses of 0.1g/ml one h after presenting the lysine-free diet. This injection increased the plasma lysine concentration one h later and kept it similar to that of the control group for the following 2 h. Chickens ate the lysine-free diet as much as the control diet when their plasma lysine concentration was kept at a similar level to the control group. Injection of saline or alanine (0.12 g, iso-nitrogenous to lysine 0.1 g) into the crop of chickens on the lysine-free diet did not bring about the variations of food intake and plasma lysine concentrations as observed in those with lysine. 4. These findings show that the food intake variation was attributed to the plasma lysine concentration in the chickens on the lysine-free diet.
    British Poultry Science 08/2014; 55(5). DOI:10.1080/00071668.2014.949623


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Top publications last week by reads

Tree Physiology 10/2015; DOI:10.1093/treephys/tpv073
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Current Opinion in Biotechnology 05/2006; 17(2):113-22. DOI:10.1016/j.copbio.2006.02.002
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