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ABSTRACT: Recent infrared spectroscopic observations have shown that proto-planetary nebulae (PPNs) are sites of active syn-thesis of organic compounds in the late stages of stellar evolution. This paper presents a study of Spitzer/Infrared Spectrograph spectra for a sample of carbon-rich PPNs, all except one of which show the unidentified 21 μm emis-sion feature. The strengths of the aromatic infrared band, 21 μm, and 30 μm features are obtained by decomposition of the spectra. The observed variations in the strengths and peak wavelengths of the features support the model that the newly synthesized organic compounds gradually change from aliphatic to aromatic characteristics as stars evolve from PPNs to planetary nebulae.The Astrophysical Journal 07/2016; 725(1):990-1001. DOI:10.1088/0004-637X/725/1/990
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ABSTRACT: Highly collimated multiple bipolar flows are detected with a 3 resolution in the HCO + (J = 3–2) and HCN (J = 3–2) lines in the young planetary nebula NGC 7027 with the Submillimeter Array. The HCO + and HCN flows coincide in location and velocity with compact and fast CO flows detected with ∼6 resolutions with other millimeter arrays. The equatorial molecular torus of NGC 7027 is captured in HCO + emission in the present observations. The HCO + emission also closely follows the H 2 emission, indicating that the present observations probe the photon-dominated region of the molecular envelope of NGC 7027.The Astrophysical Journal 05/2016; 722(1):273-280. DOI:10.1088/0004-637X/722/1/273
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ABSTRACT: WDR5 is a core component of the human mixed lineage leukemia-2 complex, which plays central roles in ER positive tumour cells and is a major driver of androgen-dependent prostate cancer cell proliferation. Given the similarities between breast and prostate cancers, we explore the potential prognostic value of WDR5 gene expression on breast cancer survival. Our findings reveal that WDR5 over-expression is associated with poor breast cancer clinical outcome in three gene expression data sets and BreastMark. The eQTL analysis reveals 130 trans-eQTL SNPs whose genes mapped with statistical significance are significantly associated with patient survival. These genes together with WDR5 are enriched with "cellular development, gene expression, cell cycle" signallings. Knocking down WDR5 in MCF7 dramatically decreases cell viability, but does not alter tumour cell response to doxorubicin. Our study reveals the prognostic value of WDR5 expression in breast cancer which is under long-range regulation of genes involved in cell cycle, and anthracycline could be coupled with treatments targeting WDR5 once such a regimen is available.PLoS ONE 09/2015; 10(9):e0124964. DOI:10.1371/journal.pone.0124964
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