Institute of Genetics and Molecular Medicine

Publications (117)

• Article: Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation.

  Hironori Ishizaki, Michaela Spitzer, Jan Wildenhain, Corina Anastasaki, Zhiqiang Zeng, Sonam Dolma, Michael Shaw, Erik Madsen, Jonathan Gitlin, Richard Marais, Mike Tyers, E Elizabeth Patton
  Disease Models and Mechanisms 3(9-10):639-51. · 4.94 Impact Factor
• Source

  Available from: braintrusters.com

  Article: Novel insights into DAPK autophagic signalling using peptide aptamer combinatorial protein-interaction screens.

  Craig Stevens, Ted R Hupp
  Autophagy 4(4):531-3. · 7.45 Impact Factor
• Article: Exemestane and aromatase inhibitors in the management of advanced breast cancer.

  J Michael Dixon
  Expert Opinion on Pharmacotherapy 03/2004; 5(2):307-16. · 3.20 Impact Factor
• Source

  Available from: epgonline.org

  Article: Extended adjuvant therapy with letrozole: reducing the risk of recurrence.

  J Michael Dixon
  Expert Review of Anti-infective Therapy 07/2006; 6(6):849-59. · 2.65 Impact Factor
• Source

  Available from: Erin Worrall

  Article: Dual-site regulation of MDM2 E3-ubiquitin ligase activity.

  Maura Wallace, Erin Worrall, Susanne Pettersson, Ted R Hupp, Kathryn L Ball
  Molecular Cell 08/2006; 23(2):251-63. · 14.18 Impact Factor
• Article: Aromatase inhibitors in early breast cancer therapy: a variety of treatment strategies.

  J Michael Dixon
  Expert Opinion on Pharmacotherapy 01/2007; 7(18):2465-79. · 3.20 Impact Factor
• Source

  Available from: Jennifer Fraser

  Article: Chemical genetics approach to identify peptide ligands that selectively stimulate DAPK-1 kinase activity.

  Jennifer A Fraser, Ted R Hupp
  Biochemistry 04/2007; 46(10):2655-73. · 3.42 Impact Factor
• Article: Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis.

  Yao Lin, Craig Stevens, Ted Hupp
  Journal of Biological Chemistry 07/2007; 282(23):16792-802. · 4.77 Impact Factor
• Article: Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2.

  Euan Murray, Ekaterina O McKenna, Lindsay R Burch, John Dillon, Pat Langridge-Smith, Walter Kolch, Andrew Pitt, Ted R Hupp
  Biochemistry 01/2008; 46(48):13742-51. · 3.42 Impact Factor
• Article: DNA methylation in mouse embryonic stem cells and development.

  Tom Latham, Nick Gilbert, Bernard Ramsahoye
  Cell and Tissue Research 02/2008; 331(1):31-55. · 3.11 Impact Factor
• Article: Prospects of neoadjuvant aromatase inhibitor therapy in breast cancer.

  J Michael Dixon
  Expert Review of Anti-infective Therapy 04/2008; 8(3):453-63. · 2.65 Impact Factor
• Article: Global initiatives for improving hospital care for children: state of the art and future prospects.

  Harry Campbell, Trevor Duke, Martin Weber, Mike English, Susanne Carai, Giorgio Tamburlini
  PEDIATRICS 05/2008; 121(4):e984-92. · 4.47 Impact Factor
• Article: Reducing early recurrence with adjuvant aromatase inhibitors: what is the evidence?

  J Michael Dixon
  The Breast 06/2008; 17(4):353-60. · 2.49 Impact Factor
• Article: An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing.

  Yao Lin, Craig Stevens, Roman Hrstka, Ben Harrison, Argyro Fourtouna, Suresh Pathuri, Borek Vojtesek, Ted Hupp
  FEBS Journal 06/2008; 275(10):2574-84. · 3.79 Impact Factor
• Article: Src and focal adhesion kinase as therapeutic targets in cancer.

  Valerie G Brunton, Margaret C Frame
  Current Opinion in Pharmacology 08/2008; 8(4):427-32. · 6.86 Impact Factor
• Article: Pathogenesis and management of Paget's disease of bone.

  Stuart H Ralston, Anne L Langston, Ian R Reid
  The Lancet 08/2008; 372(9633):155-63. · 38.28 Impact Factor
• Article: ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.

  Craig Stevens, Susanne Pettersson, Bartosz Wawrzynow, Maura Wallace, Kathryn Ball, Alicja Zylicz, Ted R Hupp
  FEBS Journal 09/2008; 275(19):4875-86. · 3.79 Impact Factor
• Article: A tal(in) of cell spreading.

  Margaret Frame, Jim Norman
  Nature Cell Biology 10/2008; 10(9):1017-9. · 19.49 Impact Factor
• Article: NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation.

  Margaret C Frame, Gareth J Inman
  Developmental cell 11/2008; 15(4):494-6. · 13.36 Impact Factor
• Article: mc1r Pathway regulation of zebrafish melanosome dispersion.

  Jennifer Richardson, Pia Rengtved Lundegaard, Natalie L Reynolds, Julia R Dorin, David J Porteous, Ian J Jackson, E Elizabeth Patton
  Zebrafish 01/2009; 5(4):289-95. · 3.08 Impact Factor
• Article: A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.

  Bryan Serrels, Alan Serrels, Susan M Mason, Christine Baldeschi, Gabrielle H Ashton, M Canel, Lorna J Mackintosh, Brendan Doyle, Tim P Green, Margaret C Frame, Owen J Sansom, Valerie G Brunton
  Carcinogenesis 01/2009; 30(2):249-57. · 5.70 Impact Factor
• Article: Common genetic variants at the MC4R locus are associated with obesity, but not with dietary energy intake or colorectal cancer in the Scottish population.

  A Tenesa, H Campbell, E Theodoratou, L Dunlop, R Cetnarskyj, S M Farrington, M G Dunlop
  International journal of obesity (2005) 01/2009; 33(2):284-8. · 4.34 Impact Factor
• Source

  Available from: PubMed Central

  Article: Breast screening has increased the number of mastectomies.

  J Michael Dixon
  Breast cancer research: BCR 01/2009; 11 Suppl 3:S19. · 5.24 Impact Factor
• Source

  Available from: PubMed Central

  Article: The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway.

  Nicola J Maclaine, Ted R Hupp
  Aging 01/2009; 1(5):490-502. · 5.13 Impact Factor
• Article: A function for the RING finger domain in the allosteric control of MDM2 conformation and activity.

  Bartosz Wawrzynow, Susanne Pettersson, Alicja Zylicz, Janice Bramham, Erin Worrall, Ted R Hupp, Kathryn L Ball
  Journal of Biological Chemistry 03/2009; 284(17):11517-30. · 4.77 Impact Factor
• Article: The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization.

  Yao Lin, Craig Stevens, Ben Harrison, Suresh Pathuri, Eliana Amin, Ted R Hupp
  Molecular and Cellular Biochemistry 04/2009; 328(1-2):101-7. · 2.06 Impact Factor
• Source

  Available from: PubMed Central

  Article: Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors.

  Corina Anastasaki, Anne L Estep, Richard Marais, Katherine A Rauen, E Elizabeth Patton
  Human Molecular Genetics 05/2009; 18(14):2543-54. · 7.64 Impact Factor
• Article: Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation.

  Emmanuelle Pion, Vikram Narayan, Mirjam Eckert, Kathryn L Ball
  Cellular signalling 06/2009; 21(10):1479-87. · 4.09 Impact Factor
• Article: Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery.

  Vikram Narayan, Mirjam Eckert, Alicja Zylicz, Maciej Zylicz, Kathryn L Ball
  Journal of Biological Chemistry 07/2009; 284(38):25889-99. · 4.77 Impact Factor
• Source

  Available from: ed.ac.uk

  Article: Systems pathology--taking molecular pathology into a new dimension.

  Dana Faratian, Robert G Clyde, John W Crawford, David J Harrison
  Nature Reviews Clinical Oncology 09/2009; 6(8):455-64. · 11.96 Impact Factor
• Article: Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo.

  Aymen I Idris, Hélène Libouban, Hervé Nyangoga, Euphemie Landao-Bassonga, Daniel Chappard, Stuart H Ralston
  Molecular Cancer Therapeutics 09/2009; 8(8):2339-47. · 5.23 Impact Factor
• Article: CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability.

  Anne-Sophie Huart, Nicola J MacLaine, David W Meek, Ted R Hupp
  Journal of Biological Chemistry 09/2009; 284(47):32384-94. · 4.77 Impact Factor
• Article: Modulation of HER3 is a marker of dynamic cell signaling in ovarian cancer: implications for pertuzumab sensitivity.

  Yoko Nagumo, Dana Faratian, Peter Mullen, David J Harrison, Max Hasmann, Simon P Langdon
  Molecular Cancer Research 10/2009; 7(9):1563-71. · 4.29 Impact Factor
• Article: MUTYH-associated polyposis and colorectal cancer.

  Malcolm G Dunlop, Susan M Farrington
  Surgical Oncology Clinics of North America 10/2009; 18(4):599-610. · 1.12 Impact Factor
• Article: Death-associated protein kinase (DAPK) and signal transduction.

  Ted R Hupp
  FEBS Journal 10/2009; 277(1):47. · 3.79 Impact Factor
• Article: Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death.

  Yao Lin, Ted R Hupp, Craig Stevens
  FEBS Journal 10/2009; 277(1):48-57. · 3.79 Impact Factor
• Article: Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin.

  Zhiqiang Zeng, Jennifer Richardson, Daniel Verduzco, David L Mitchell, E Elizabeth Patton
  Zebrafish 12/2009; 6(4):405-15. · 3.08 Impact Factor
• Source

  Available from: PubMed Central

  Article: Systems pathology.

  Dana Faratian
  Breast cancer research: BCR 01/2010; 12 Suppl 4:S4. · 5.24 Impact Factor
• Source

  Available from: bpa-pathology.com

  Article: Xmrk in medaka: a new genetic melanoma model.

  E Elizabeth Patton, Rodney S Nairn
  Journal of Investigative Dermatology 01/2010; 130(1):14-7. · 6.31 Impact Factor
• Source

  Available from: Andrew H Sims

  Article: Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer.

  Karen J Taylor, Andrew H Sims, Liang Liang, Dana Faratian, Morwenna Muir, Graeme Walker, Barbara Kuske, J Michael Dixon, David A Cameron, David J Harrison, Simon P Langdon
  Breast cancer research: BCR 01/2010; 12(3):R39. · 5.24 Impact Factor
• Source

  Available from: Ada Delaney

  Article: Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin.

  Ada Delaney, Margaret Keighren, Susan M Fleetwood-Walker, Ian J Jackson
  PLoS ONE 01/2010; 5(9):e12498. · 4.09 Impact Factor
• Source

  Available from: Andrew H Sims

  Article: Correcting for intra-experiment variation in Illumina BeadChip data is necessary to generate robust gene-expression profiles.

  Robert R Kitchen, Vicky S Sabine, Andrew H Sims, E Jane Macaskill, Lorna Renshaw, Jeremy S Thomas, Jano I van Hemert, J Michael Dixon, John M S Bartlett
  BMC Genomics 02/2010; 11:134. · 4.07 Impact Factor
• Source

  Available from: PubMed Central

  Article: Genetic and environmental melanoma models in fish.

  E Elizabeth Patton, David L Mitchell, Rodney S Nairn
  Pigment Cell & Melanoma Research 03/2010; 23(3):314-37. · 5.06 Impact Factor
• Article: The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2.

  Erin G Worrall, Liam Worrall, Elizabeth Blackburn, Malcolm Walkinshaw, Ted R Hupp
  Journal of Molecular Biology 03/2010; 398(3):414-28. · 4.00 Impact Factor
• Source

  Available from: PubMed Central

  Article: Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme.

  Katan Patel, Jacqueline Dickson, Shahida Din, Kenneth Macleod, Duncan Jodrell, Bernard Ramsahoye
  Nucleic Acids Research 03/2010; 38(13):4313-24. · 8.03 Impact Factor
• Article: The molecular dynamics of MDM2.

  Judith Nicholson, Ted R Hupp
  Cell cycle (Georgetown, Tex.) 05/2010; 9(10):1878-81. · 5.36 Impact Factor
• Article: Increased incidence of visceral metastases in scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype.

  Charlie Gourley, Caroline O Michie, Patricia Roxburgh, Timothy A Yap, Sharon Harden, Jim Paul, Kalpana Ragupathy, Radha Todd, Russell Petty, Nick Reed, Richard L Hayward, Paul Mitchell, Tzyvia Rye, Jan H M Schellens, Jan Lubinski, James Carmichael, Stan B Kaye, Melanie Mackean, Michelle Ferguson
  Journal of Clinical Oncology 05/2010; 28(15):2505-11. · 18.37 Impact Factor
• Source

  Available from: Kurt I Anderson

  Article: A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.

  Bryan Serrels, Emma Sandilands, Alan Serrels, George Baillie, Miles D Houslay, Valerie G Brunton, Marta Canel, Laura M Machesky, Kurt I Anderson, Margaret C Frame
  Current biology: CB 06/2010; 20(12):1086-92. · 10.99 Impact Factor
• Source

  Available from: Andrew H Sims

  Article: Gene expression profiling of response to mTOR inhibitor everolimus in pre-operatively treated post-menopausal women with oestrogen receptor-positive breast cancer.

  Vicky S Sabine, Andrew H Sims, E Jane Macaskill, Lorna Renshaw, Jeremy S Thomas, J Michael Dixon, John M S Bartlett
  Breast Cancer Research and Treatment 07/2010; 122(2):419-28. · 4.43 Impact Factor
• Article: Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.

  Albert Tenesa, Evropi Theodoratou, Farhat V N Din, Susan M Farrington, Roseanne Cetnarskyj, Rebecca A Barnetson, Mary E Porteous, Harry Campbell, Malcolm G Dunlop
  Clinical Cancer Research 07/2010; 16(14):3754-9. · 7.74 Impact Factor