Centre for Cardiovascular Science

Publications (370)

• Article: The role and regulation of 11β-hydroxysteroid dehydrogenase type 1 in the inflammatory response

  Karen E. Chapman, Agnes E. Coutinho, Mohini Gray, James S. Gilmour, John S. Savill, Jonathan R. Seckl
  Molecular and Cellular Endocrinology.
• Article: The role of 11β-hydroxysteroid dehydrogenases in the brain

  Megan C. Holmes, Jonathan R. Seckl
  Molecular and Cellular Endocrinology.
• Article: 11β-Hydroxysteroid dehydrogenase type 1—A role in inflammation?

  Karen E. Chapman, James S. Gilmour, Agnes E. Coutinho, John S. Savill, Jonathan R. Seckl
  Molecular and Cellular Endocrinology.
• Article: Acute systemic inflammation enhances endothelium-dependent tissue plasminogen activator release in men

  Stanley Chia, Christopher A Ludlam, Keith A.A Fox, David E Newby
  Journal of the American College of Cardiology.
• Article: Plasma TAFI and soluble CD40 ligand do not predict reperfusion following thrombolysis for acute myocardial infarction

  Nicholas L.M. Cruden, Catriona Graham, Scott A. Harding, Christopher A. Ludlam, Keith A.A. Fox, David E. Newby
  Thrombosis Research.
• Article: Phenotypic analysis of mice bearing targeted deletions of 11β-hydroxysteroid dehydrogenases 1 and 2 genes

  Megan C. Holmes, Yuri Kotelevtsev, John J. Mullins, Jonathan R. Seckl
  Molecular and Cellular Endocrinology.
• Article: 5-year outcome of an interventional strategy in non-ST-elevation acute coronary syndrome: the British Heart Foundation RITA 3 randomised trial.

  K A A Fox, P Poole-Wilson, T C Clayton, R A Henderson, T R D Shaw, D J Wheatley, R Knight, S J Pocock
  The Lancet 366(9489):914-20. · 38.28 Impact Factor
• Article: Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity.

  Saibal K Biswas, Danny McClure, Luis A Jimenez, Ian L Megson, Irfan Rahman
  Antioxidants and Redox Signaling 7(1-2):32-41. · 8.46 Impact Factor
• Source

  Available from: David John Webb

  Article: COX-2 selective inhibitors--important lessons learned.

  Simon R J Maxwell, David J Webb
  The Lancet 365(9458):449-51. · 38.28 Impact Factor
• Article: Medroxyprogesterone acetate inhibits the cardioprotective effect of estrogen in experimental ischemia-reperfusion injury.

  Helen L Jeanes, Payong Wanikiat, Isam Sharif, Gillian A Gray
  Menopause 13(1):80-6. · 3.76 Impact Factor
• Article: Impact of intermittent claudication on quality of life. The Scottish Vascular Audit Group.

  J P Pell
  European Journal of Vascular and Endovascular Surgery 06/1995; 9(4):469-72. · 2.99 Impact Factor
• Source

  Available from: David John Webb

  Article: Localization and function of ET-1 and ET receptors in small arteries post-myocardial infarction: upregulation of smooth muscle ET(B) receptors that modulate contraction.

  G A Gray, E J Mickley, D J Webb, P E McEwan
  British Journal of Pharmacology 09/2000; 130(8):1735-44. · 4.41 Impact Factor
• Article: Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure.

  A A Miller, I L Megson, G A Gray
  British Journal of Pharmacology 10/2000; 131(1):29-36. · 4.41 Impact Factor
• Source

  Available from: David John Webb

  Article: Oestrogen and the cardiovascular system: the good, the bad and the puzzling.

  G A Gray, I Sharif, D J Webb, J R Seckl
  Trends in Pharmacological Sciences 04/2001; 22(3):152-6. · 10.93 Impact Factor
• Article: Human urotensin II increases coronary perfusion pressure in the isolated rat heart: potentiation by nitric oxide synthase and cyclooxygenase inhibition.

  G A Gray, M R Jones, I Sharif
  Life Sciences 07/2001; 69(2):175-80. · 2.53 Impact Factor
• Source

  Available from: David John Webb

  Article: Urotensin II: a new mediator in cardiopulmonary regulation?

  J Affolter, D J Webb
  The Lancet 10/2001; 358(9284):774-5. · 38.28 Impact Factor
• Article: Investigation of the endothelin system in experimental heart failure.

  Gillian A Gray, Lorcan Sherry
  Methods in molecular biology (Clifton, N.J.) 02/2002; 206:217-27.
• Article: The evidence behind inhibitor treatment with recombinant factor VIIa.

  Christopher A Ludlam
  Pathophysiology of Haemostasis and Thrombosis 02/2002; 32 Suppl 1:13-8. · 2.23 Impact Factor
• Article: Transgenesis in the rat.

  Linda J Mullins, Gillian Brooker, John J Mullins
  Methods in molecular biology (Clifton, N.J.) 02/2002; 180:255-70.
• Article: Self-monitored blood pressure: a role in clinical practice?

  Paul L Padfield
  Blood Pressure Monitoring 03/2002; 7(1):41-4. · 1.52 Impact Factor
• Article: Atherosclerosis, cigarette smoking, and endogenous fibrinolysis: is there a direct link?

  Stanley Chia, David E Newby
  Current Atherosclerosis Reports 04/2002; 4(2):143-8. · 2.66 Impact Factor
• Source

  Available from: David John Webb

  Article: The effect of oxidative stress on endothelium-dependent and nitric oxide donor-induced relaxation: implications for nitrate tolerance.

  Inderraj S Hanspal, Kesson S Magid, David J Webb, Ian L Megson
  Nitric Oxide 06/2002; 6(3):263-70. · 3.55 Impact Factor
• Article: Nitric oxide donor drugs: current status and future trends.

  Ian L Megson, David J Webb
  Expert Opinion on Investigational Drugs 06/2002; 11(5):587-601. · 5.27 Impact Factor
• Article: Invasive assessment of the coronary circulation: intravascular ultrasound and Doppler.

  David E Newby, Keith A A Fox
  British Journal of Clinical Pharmacology 07/2002; 53(6):561-75. · 2.96 Impact Factor
• Article: Marked bradykinin-induced tissue plasminogen activator release in patients with heart failure maintained on long-term angiotensin-converting enzyme inhibitor therapy.

  Fraser N Witherow, Pamela Dawson, Christopher A Ludlam, Keith A A Fox, David E Newby
  Journal of the American College of Cardiology 09/2002; 40(5):961-6. · 14.16 Impact Factor
• Source

  Available from: Dawn E W Livingstone

  Article: Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood?

  Mark E Cleasby, Dawn E W Livingstone, Moffat J Nyirenda, Jonathan R Seckl, Brian R Walker
  European Journal of Endocrinology 01/2003; 148(1):129-38. · 3.42 Impact Factor
• Article: Acute systemic inflammation enhances endothelium-dependent tissue plasminogen activator release in men.

  Stanley Chia, Christopher A Ludlam, Keith A A Fox, David E Newby
  Journal of the American College of Cardiology 01/2003; 41(2):333-9. · 14.16 Impact Factor
• Article: Novel role for low molecular weight plasma thiols in nitric oxide-mediated control of platelet function.

  Michael S Crane, Richard Ollosson, Kevin P Moore, Adriano G Rossi, Ian L Megson
  Journal of Biological Chemistry 01/2003; 277(49):46858-63. · 4.77 Impact Factor
• Article: Human insulin resistance: the role of glucocorticoids.

  Rebecca M Reynolds, Brian R Walker
  Diabetes Obesity and Metabolism 02/2003; 5(1):5-12. · 3.38 Impact Factor
• Article: Mineralocorticoid mechanisms.

  Brian R Walker
  Hormone Research 02/2003; 59 Suppl 1:55. · 2.48 Impact Factor
• Source

  Available from: David John Webb

  Article: A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury.

  Mark R Miller, Inderraj S Hanspal, Patrick W F Hadoke, David E Newby, Adriano G Rossi, David J Webb, Ian L Megson
  Cardiovascular Research 04/2003; 57(3):853-60. · 6.06 Impact Factor
• Article: Intra-arterial tumor necrosis factor-alpha impairs endothelium-dependent vasodilatation and stimulates local tissue plasminogen activator release in humans.

  Stanley Chia, Motaz Qadan, Richard Newton, Christopher A Ludlam, Keith A A Fox, David E Newby
  Arteriosclerosis Thrombosis and Vascular Biology 04/2003; 23(4):695-701. · 6.37 Impact Factor
• Article: Is 11beta-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats.

  Dawn E W Livingstone, Brian R Walker
  Journal of Pharmacology and Experimental Therapeutics 05/2003; 305(1):167-72. · 3.83 Impact Factor
• Source

  Available from: David John Webb

  Article: Noninvasive assessment of arterial stiffness and risk of atherosclerotic events.

  James J Oliver, David J Webb
  Arteriosclerosis Thrombosis and Vascular Biology 05/2003; 23(4):554-66. · 6.37 Impact Factor
• Source

  Available from: David John Webb

  Article: Validation of laser Doppler flowmetry coupled with intra-dermal injection for investigating effects of vasoactive agents on the skin microcirculation in man.

  Stephen J Leslie, Jonathan Affolter, Martin A Denvir, David J Webb
  European Journal of Clinical Pharmacology 06/2003; 59(2):99-102. · 2.85 Impact Factor
• Article: A randomised study of home-based electrical stimulation of the legs and conventional bicycle exercise training for patients with chronic heart failure.

  Stuart Harris, John P LeMaitre, Graham Mackenzie, Keith A A Fox, Martin A Denvir
  European Heart Journal 06/2003; 24(9):871-8. · 10.48 Impact Factor
• Source

  Available from: David John Webb

  Article: Management of chronic heart failure due to systolic left ventricular dysfunction by cardiologist and non-cardiologist physicians.

  Sinéad P McKee, Stephen J Leslie, John P LeMaitre, David J Webb, Martin A Denvir
  European Journal of Heart Failure 08/2003; 5(4):549-55. · 4.90 Impact Factor
• Source

  Available from: David John Webb

  Article: Bradykinin receptor antagonism and endothelial tissue plasminogen activator release in humans.

  Fraser N Witherow, Pamela Dawson, Christopher A Ludlam, David J Webb, Keith A A Fox, David E Newby
  Arteriosclerosis Thrombosis and Vascular Biology 09/2003; 23(9):1667-70. · 6.37 Impact Factor
• Article: 11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease.

  Brian R Walker, Jonathan R Seckl
  Expert opinion on therapeutic targets 01/2004; 7(6):771-83. · 3.72 Impact Factor
• Article: Nuclear transfer in rodents.

  Linda J Mullins, Ian Wilmut, John J Mullins
  The Journal of Physiology 02/2004; 554(Pt 1):4-12. · 4.72 Impact Factor
• Article: Omega 3 fatty acids and cardiovascular disease--fishing for a natural treatment.

  Jehangir N Din, David E Newby, Andrew D Flapan
  BMJ (Clinical research ed.). 02/2004; 328(7430):30-5.
• Article: Angiotensin antagonism in patients with heart failure: ACE inhibitors, angiotensin receptor antagonists or both?

  Nicholas L M Cruden, David E Newby
  American Journal of Cardiovascular Drugs 02/2004; 4(6):345-53. · 1.77 Impact Factor
• Article: Change in circulating cytokines after 2 forms of exercise training in chronic stable heart failure.

  John P LeMaitre, Stuart Harris, Keith A A Fox, Martin Denvir
  American heart journal 02/2004; 147(1):100-5. · 4.65 Impact Factor
• Article: 11beta-hydroxysteroid dehydrogenase type 1 in obesity.

  Brian R Walker
  Obesity research 02/2004; 12(1):1-3. · 4.95 Impact Factor
• Source

  Available from: PubMed Central

  Article: Insights from the rat genome sequence.

  Linda J Mullins, John J Mullins
  Genome biology 02/2004; 5(5):221. · 6.63 Impact Factor
• Source

  Available from: David John Webb

  Article: Hyperuricaemia does not impair cardiovascular function in healthy adults.

  W S Waring, S H Adwani, O Breukels, D J Webb, S R J Maxwell
  Heart (British Cardiac Society) 03/2004; 90(2):155-9. · 4.22 Impact Factor
• Source

  Available from: David John Webb

  Article: Extracellular nitric oxide release mediates soluble guanylate cyclase-independent vasodilator action of spermine NONOate: comparison with other nitric oxide donors in isolated rat femoral arteries.

  M R Miller, K Okubo, M J Roseberry, D J Webb, I L Megson
  Journal of Cardiovascular Pharmacology 03/2004; 43(3):440-51. · 2.29 Impact Factor
• Source

  Available from: David John Webb

  Article: Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade.

  Jane Goddard, Neil R Johnston, Malcolm F Hand, Allan D Cumming, Ton J Rabelink, Andrew J Rankin, David J Webb
  Circulation 04/2004; 109(9):1186-93. · 14.74 Impact Factor
• Article: Long-term management of atherothrombosis.

  Keith A Fox
  Hospital medicine (London, England: 1998) 05/2004; 65(4):206-9. · 0.33 Impact Factor
• Article: Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein.

  H A Alhadi, K A A Fox
  QJM: monthly journal of the Association of Physicians 05/2004; 97(4):187-98. · 2.33 Impact Factor