The University of Edinburgh

Edinburgh, Scotland, United Kingdom

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School of GeoSciences
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School of Biological Sciences
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School of Informatics
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    ABSTRACT: Narrow-bore instruments are commonly perceived to be brighter than wide-bore models of the same kind of instrument. This effect is closely related to the effect of the bore profile of a brass instrument on the potential for non-linear propagation of sound within the tube. This paper reports on practical tests with trumpets of different bore diameters, experiments with loudspeaker excitation of instruments, and simulations. The brassiness curves of a range of low instruments with similar Brassiness Potential but differing in their absolute bore diameters are compared. The relative importance of the two effects is explored.
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    ABSTRACT: This paper describes some of the lessons learned from the FireGrid project. It starts with a brief overview of the project. The discussion of the lessons learned that follows is intended for others attempting to develop a similar system, where sensor data is used to steer a super-real time simulation in order to generate predictions that will provide decision support for emergency responders.
    Crisis Management. 04/2014;
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    ABSTRACT: Specialised chromatin in which canonical histone H3 is replaced by CENP-A, an H3 related protein, is a signature of active centromeres and provides the foundation for kinetochore assembly. The location of centromeres is not fixed since centromeres can be inactivated and new centromeres can arise at novel locations independently of specific DNA sequence elements. Therefore, the establishment and maintenance of CENP-A chromatin and kinetochores provide an exquisite example of genuine epigenetic regulation. The composition of CENP-A nucleosomes is contentious but several studies suggest that, like regular H3 particles, they are octamers. Recent analyses have provided insight into how CENP-A is recognised and propagated, identified roles for post-translational modifications and dissected how CENP-A recruits other centromere proteins to mediate kinetochore assembly.
    Current opinion in cell biology 02/2014; 26C:41-50.


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    Drummond Street, EH8 9XP, Edinburgh, Scotland, United Kingdom
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Trends in Biochemical Sciences 11/1997; 22(10):388-93.

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