Edinburgh, Scotland, United Kingdom

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School of GeoSciences
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    ABSTRACT: Narrow-bore instruments are commonly perceived to be brighter than wide-bore models of the same kind of instrument. This effect is closely related to the effect of the bore profile of a brass instrument on the potential for non-linear propagation of sound within the tube. This paper reports on practical tests with trumpets of different bore diameters, experiments with loudspeaker excitation of instruments, and simulations. The brassiness curves of a range of low instruments with similar Brassiness Potential but differing in their absolute bore diameters are compared. The relative importance of the two effects is explored.
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    ABSTRACT: ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common neurodegenerative diseases downstream of the endoplasmic reticulum (ER) stress response. Despite accumulating correlative evidence supporting a neuroprotective role of ERp57, the contribution of this foldase to the physiology of the nervous system remains unknown. Here we developed a transgenic mouse model that overexpresses ERp57 in the nervous system under the control of the prion promoter. We analyzed the susceptibility of ERp57 transgenic mice to undergo neurodegeneration. Unexpectedly, ERp57 overexpression did not affect dopaminergic neuron loss and striatal denervation after injection of a Parkinson's disease-inducing neurotoxin. In sharp contrast, ERp57 transgenic animals presented enhanced locomotor recovery after mechanical injury to the sciatic nerve. These protective effects were associated with enhanced myelin removal, macrophage infiltration and axonal regeneration. Our results suggest that ERp57 specifically contributes to peripheral nerve regeneration, whereas its activity is dispensable for the survival of a specific neuronal population of the central nervous system. These results demonstrate for the first time a functional role of a component of the ER proteostasis network in peripheral nerve regeneration.
    PLoS ONE 09/2015; 10(9):e0136620. DOI:10.1371/journal.pone.0136620
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    ABSTRACT: Quasars that allow the study of intergalactic medium (IGM) He ii are very rare, since they must be at high redshift along sightlines free of substantial hydrogen absorption, but recent work has dramatically expanded the number of such quasars known. We analyze two dozen higher-redshift (z = 3.1–3.9) low-resolution He ii quasar spectra from the Hubble Space Telescope and find that their He ii Gunn–Peterson troughs suggest exclusion of very early and very late reionization models, favoring a reionization redshift of z ∼ 3. Although the data quality is not sufficient to reveal details such as the expected redshift evolution of helium opacity, we obtain the first ensemble measure of helium opacity at high redshift averaged over many sightlines: τ = 4.90 at z ∼ 3.3. We also find that it would be very difficult to observe the IGM red wing of absorption from the beginning of He ii reionization, but depending on the redshift of reionization and the size of ionization zones, it might be possible to do so in some objects with the current generation of UV spectrographs.
    The Astrophysical Journal 08/2015; 726(2). DOI:10.1088/0004-637X/726/2/111


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    Drummond Street, EH8 9XP, Edinburgh, Scotland, United Kingdom
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Top publications last week by reads

New Phytologist 09/2015; DOI:10.1111/nph.13646
136 Reads
Medicine &amp Science in Sports &amp Exercise 01/2001; DOI:10.4324/9780203019320
126 Reads

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