Centre of Diabetes

Publications (82)

• Article: Antecedent protein restriction and high-fat feeding interactively sensitise the leptin response to elevated insulin

  M.J. Holness, M.C. Sugden
  Molecular and Cellular Endocrinology.
• Article: Glucose utilization by skeletal muscles in vivo in experimental hyperthyroidism in the rat.

  M C Sugden, Y L Liu, M J Holness
  Biochemical Journal 11/1990; 271(2):421-5. · 4.90 Impact Factor
• Source

  Available from: nih.gov

  Article: Glucose utilization and disposal in cardiothoracic and skeletal muscles during the starved-to-fed transition in the rat.

  M C Sugden, Y L Liu, M J Holness
  Biochemical Journal 12/1990; 272(1):133-7. · 4.90 Impact Factor
• Article: Substrate interactions in the development of insulin resistance in type II diabetes and obesity.

  M C Sugden, M J Holness
  Journal of Endocrinology 12/1990; 127(2):187-90. · 3.55 Impact Factor
• Article: Glucose utilization by interscapular brown adipose tissue in vivo during nutritional transitions in the rat.

  M J Holness, Y L Liu, J S Beech, M C Sugden
  Biochemical Journal 02/1991; 273(Pt 1):233-5. · 4.90 Impact Factor
• Source

  Available from: nih.gov

  Article: Glucose disposal by skeletal muscle in response to re-feeding after progressive starvation.

  M J Holness, M C Sugden
  Biochemical Journal 08/1991; 277 ( Pt 2):429-33. · 4.90 Impact Factor
• Source

  Available from: nih.gov

  Article: Progressive suppression of muscle glucose utilization during pregnancy.

  M J Holness, K K Changani, M C Sugden
  Biochemical Journal 01/1992; 280 ( Pt 2):549-52. · 4.90 Impact Factor
• Article: Cardiac glucose metabolism during pregnancy.

  M C Sugden, K K Changani, J Bentley, M J Holness
  Biochemical Society Transactions 06/1992; 20(2):195S. · 3.71 Impact Factor
• Article: Skeletal muscle glucose utilization in response to a decreased meal frequency.

  M J Holness, R M Howard, J Bentley, M C Sugden
  Biochemical Society Transactions 06/1992; 20(2):196S. · 3.71 Impact Factor
• Article: Glucose utilization by skeletal muscle during pregnancy.

  M J Holness, J Bentley
  Biochemical Society Transactions 06/1992; 20(2):197S. · 3.71 Impact Factor
• Source

  Available from: nih.gov

  Article: Variations in hepatic carbon flux during unrestricted feeding.

  M C Sugden, R M Howard, M J Holness
  Biochemical Journal 07/1992; 284 ( Pt 3):721-4. · 4.90 Impact Factor
• Article: Glucose utilization and disposition by skeletal muscle during unrestricted feeding.

  M J Holness, R M Howard, M C Sugden
  Biochemical Journal 10/1992; 286 ( Pt 2):395-8. · 4.90 Impact Factor
• Source

  Available from: nih.gov

  Article: Mechanisms regulating cardiac fuel selection in hyperthyroidism.

  M C Sugden, M J Holness, Y L Liu, D M Smith, L G Fryer, Y T Kruszynska
  Biochemical Journal 10/1992; 286 ( Pt 2):513-7. · 4.90 Impact Factor
• Article: Mechanisms involved in the coordinate regulation of strategic enzymes of glucose metabolism.

  M C Sugden, R M Howard, M R Munday, M J Holness
  Advances in Enzyme Regulation 02/1993; 33:71-95.
• Article: Cardiac lipoprotein lipase activities in relation to glucose utilization during progressive starvation.

  M C Sugden, R M Howard
  Biochemical Society Transactions 06/1993; 21(2):142S. · 3.71 Impact Factor
• Article: Factors contributing to the hypertriacylglycerolaemia of late pregnancy.

  R M Howard, M C Sugden
  Biochemical Society Transactions 06/1993; 21(2):143S. · 3.71 Impact Factor
• Article: Effects of diet and hormonal status on brown fat lipoprotein lipase activity.

  R M Howard, K A Orfali, M C Sugden
  Biochemical Society Transactions 09/1993; 21 ( Pt 3)(3):310S. · 3.71 Impact Factor
• Article: Effects of pregnancy on agonist-stimulated PI hydrolysis in cardiomyocytes.

  K A Orfali, P H Sugden, M C Sugden
  Biochemical Society Transactions 12/1993; 21(4):363S. · 3.71 Impact Factor
• Source

  Available from: fasebj.org

  Article: Interactive regulation of the pyruvate dehydrogenase complex and the carnitine palmitoyltransferase system.

  M C Sugden, M J Holness
  The FASEB Journal 02/1994; 8(1):54-61. · 5.71 Impact Factor
• Article: The role of the glucose/fatty acid cycle in the selective modulation of non-oxidative and oxidative glucose disposal by oxidative muscle in late pregnancy.

  M C Sugden, M J Holness
  Biological chemistry Hoppe-Seyler 03/1994; 375(2):141-7.
• Article: Hypertriglyceridaemia precedes impaired muscle glucose utilization during fructose feeding.

  M J Holness
  Biochemical Society Transactions 06/1994; 22(2):105S. · 3.71 Impact Factor
• Article: Site-selective modulation of enzymes of cardiac fuel utilization by a diet rich in fat.

  K A Orfali, R M Grimshaw, M C Sugden
  Biochemical Society Transactions 06/1994; 22(2):106S. · 3.71 Impact Factor
• Article: Interactive effects of alpha-adrenergic agonists and increased cell volume on deoxyglucose uptake and phosphorylation in isolated ventricular myocytes.

  K A Orfali, M C Sugden
  Biochemical Society Transactions 06/1994; 22(2):162S. · 3.71 Impact Factor
• Article: Regional variations in metabolic responses of white adipose tissue to food restriction.

  M C Sugden, R M Grimshaw, H Lall, M J Holness
  The American journal of physiology 01/1995; 267(6 Pt 1):E892-9.
• Article: Interactive effects of insulin and triiodothyronine on pyruvate dehydrogenase kinase activity in cardiac myocytes.

  K A Orfali, L G Fryer, M J Holness, M C Sugden
  Journal of Molecular and Cellular Cardiology 04/1995; 27(3):901-8. · 5.17 Impact Factor
• Article: Modulation of in vivo insulin action by dietary protein during pregnancy.

  M C Sugden, M J Holness
  The American journal of physiology 05/1995; 268(4 Pt 1):E722-9.
• Article: The long-term regulation of skeletal muscle pyruvate dehydrogenase kinase by dietary lipid is dependent on fatty acid composition.

  L G Fryer, K A Orfali, M J Holness, E D Saggerson, M C Sugden
  European Journal of Biochemistry 06/1995; 229(3):741-8. · 3.58 Impact Factor
• Article: Mechanisms underlying suppression of glucose oxidation in insulin-resistant states.

  M C Sugden, M J Holness
  Biochemical Society Transactions 06/1995; 23(2):314-20. · 3.71 Impact Factor
• Source

  Available from: nutrition.org

  Article: The pyruvate dehydrogenase complex: nutrient control and the pathogenesis of insulin resistance.

  M C Sugden, K A Orfali, M J Holness
  Journal of Nutrition 07/1995; 125(6 Suppl):1746S-1752S. · 3.92 Impact Factor
• Article: Increased hepatic pyruvate dehydrogenase kinase activity in fed hyperthyroid rats: studies in vivo and with cultured hepatocytes.

  M C Sugden, L G Fryer, D A Priestman, K A Orfali, M J Holness
  Molecular and Cellular Endocrinology 06/1996; 119(2):219-24. · 4.19 Impact Factor
• Article: Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes.

  D A Priestman, K A Orfali, M C Sugden
  Biochemical Society Transactions 03/1997; 25(1):101S. · 3.71 Impact Factor
• Source

  Available from: nih.gov

  Article: Studies of the long-term regulation of hepatic pyruvate dehydrogenase kinase.

  M C Sugden, L G Fryer, K A Orfali, D A Priestman, E Donald, M J Holness
  Biochemical Journal 02/1998; 329 ( Pt 1):89-94. · 4.90 Impact Factor
• Article: Hyperthyroidism facilitates cardiac fatty acid oxidation through altered regulation of cardiac carnitine palmitoyltransferase: studies in vivo and with cardiac myocytes.

  M C Sugden, D A Priestman, K A Orfali, M J Holness
  Hormone and Metabolic Research 06/1999; 31(5):300-6. · 2.19 Impact Factor
• Article: Protein restriction during early development enhances insulin responsiveness but selectively impairs sensitivity to insulin at low concentrations in white adipose tissue during a later pregnancy.

  M J Holness, L G Fryer, M C Sugden
  British Journal Of Nutrition 06/1999; 81(6):481-9. · 3.01 Impact Factor
• Source

  Available from: ncbi.nlm.nih.gov

  Article: Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of Type 2 diabetes mellitus.

  M J Holness, M L Langdown, M C Sugden
  Biochemical Journal 09/2000; 349 Pt 3:657-65. · 4.90 Impact Factor
• Article: Antecedent protein restriction and high-fat feeding interactively sensitise the leptin response to elevated insulin.

  M J Holness, M C Sugden
  Molecular and Cellular Endocrinology 03/2001; 173(1-2):53-62. · 4.19 Impact Factor
• Article: High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts.

  Sangeeta Somanath, Sebastian Barg, Catriona Marshall, Christopher J Silwood, Mark D Turner
  Biochemical and Biophysical Research Communications 09/2009; 389(2):241-6. · 2.48 Impact Factor
• Article: PPAR control: it's SIRTainly as easy as PGC.

  Mary C Sugden, Paul W Caton, Mark J Holness
  Journal of Endocrinology 09/2009; 204(2):93-104. · 3.55 Impact Factor
• Article: Rethinking phosphatidylinositol 3-monophosphate.

  Marco Falasca, Tania Maffucci
  Biochimica et Biophysica Acta 10/2009; 1793(12):1795-803. · 4.66 Impact Factor
• Article: The histogenesis of regenerative nodules in human liver cirrhosis.

  Wey-Ran Lin, Siew-Na Lim, Stuart A C McDonald, Trevor Graham, Victoria L Wright, Claire L Peplow, Adam Humphries, Hemant M Kocher, Nicholas A Wright, Amar P Dhillon, Malcolm R Alison
  Hepatology 11/2009; 51(3):1017-26. · 11.66 Impact Factor
• Source

  Available from: Marco Falasca

  Article: A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.

  M Falasca, D Chiozzotto, H Y Godage, M Mazzoletti, A M Riley, S Previdi, B V L Potter, M Broggini, T Maffucci
  British Journal of Cancer 01/2010; 102(1):104-14. · 5.04 Impact Factor
• Article: PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs.

  Marco Falasca
  Current pharmaceutical design 02/2010; 16(12):1410-6. · 4.41 Impact Factor
• Source

  Available from: qmul.ac.uk

  Article: Hypoxia increases Sca-1/CD44 co-expression in murine mesenchymal stem cells and enhances their adipogenic differentiation potential.

  M G Valorani, A Germani, W R Otto, L Harper, A Biddle, C P Khoo, W R Lin, M I Hawa, P Tropel, M P Patrizi, P Pozzilli, M R Alison
  Cell and Tissue Research 05/2010; 341(1):111-20. · 3.11 Impact Factor
• Article: Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function.

  Mark J Holness, Paul W Caton, Mary C Sugden
  Nutrition 05/2010; 26(5):491-501. · 3.03 Impact Factor
• Article: Stem cells in cancer: instigators and propagators?

  Malcolm R Alison, Shahriar Islam, Nicholas A Wright
  Journal of Cell Science 07/2010; 123(Pt 14):2357-68. · 6.11 Impact Factor
• Article: Key role of phosphoinositide 3-kinase class IB in pancreatic cancer.

  Charlotte E Edling, Federico Selvaggi, Richard Buus, Tania Maffucci, Pierluigi Di Sebastiano, Helmut Friess, Paolo Innocenti, Hemant M Kocher, Marco Falasca
  Clinical Cancer Research 09/2010; 16(20):4928-37. · 7.74 Impact Factor
• Article: Phosphoinositide 3-kinase pathway inhibitors: pharmacology, metabolism & drug development.

  Marco Falasca
  Current Medicinal Chemistry 01/2011; 18(18):2673. · 4.86 Impact Factor
• Article: mTOR inhibitors: facing new challenges ahead.

  I Mavrommati, T Maffucci
  Current Medicinal Chemistry 01/2011; 18(18):2743-62. · 4.86 Impact Factor
• Article: Chronic inflammation and hepatocellular carcinoma.

  Malcolm R Alison, Linda J Nicholson, Wey-Ran Lin
  Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 01/2011; 185:135-48.
• Source

  Available from: Stephen E Greenwald

  Article: Inbuilt mechanisms for overcoming functional problems inherent in hepatic microlobular structure.

  Robert D Cohen, Christopher L Brown, Carole Nickols, Pauline Levey, Barbara J Boucher, Stephen E Greenwald, Wen Wang
  Computational and Mathematical Methods in Medicine 01/2011; 2011:185845. · 0.68 Impact Factor