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School of Health and Biosciences
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Polytechnic School
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School of Medicine
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    ABSTRACT: Objective To present the initial results of first three years of implementation of a genetic evaluation test for bone marrow-derived mesenchymal stem cells in a Cell Technology Center. Methods A retrospective study was carried out of 21 candidates for cell therapy. After the isolation of bone marrow mononuclear cells by density gradient, mesenchymal stem cells were cultivated and expanded at least until the second passage. Cytogenetic analyses were performed before and after cell expansion (62 samples) using G-banded karyotyping. Results All the samples analyzed, before and after cell expansion, had normal karyotypes, showing no clonal chromosomal changes. Signs of chromosomal instability were observed in 11 out of 21 patients (52%). From a total of 910 analyzed metaphases, five chromatid gaps, six chromatid breaks and 14 tetraploid cells were detected giving as total of 25 metaphases with chromosome damage (2.75%). Conclusion The absence of clonal chromosomal aberrations in our results for G-banded karyotyping shows the maintenance of chromosomal stability of bone marrow-derived mesenchymal stem cells until the second passage; however, signs of chromosomal instability such as chromatid gaps, chromosome breaks and tetraploidy indicate that the long-term cultivation of these cells can provide an intermediate step for tumorigenesis.
    Revista Brasileira de Hematologia e Hemoterapia 05/2014; 36(3):202–207.
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    ABSTRACT: Introduction: Fibromyalgia syndrome (FMS) is a chronic disease that causes pain and fatigue, presenting a negative impact on quality of life. Exercise helps maintaining physical fitness and influences directly on the improvement of quality of life. Objective: Develop a protocol for health-related physical fitness assessment of patients with FMS with tests that are feasible and appropriate for this population. Method: An exploratory and analytical literature review was performed, seeking to determine the tests used by the scientific community. With this in mind, we performed a literature revision through the use of virtual libraries databases: PubMed, Bireme, Banco de Teses e Dissertações da Capes and Biblioteca Digital Brasileira de Teses e Dissertações, published in between 1992-2012. Results: A variety of tests was found; the following, by number of citations, stood out: Body Mass Index (BMI) and bioimpedance; 6-minute walk; handgrip strength (dynamometer, 1RM [Repetition Maximum]); Sit and reach and Shoulder flexibility; Foot Up and Go, and Flamingo balance. Conclusion: These are the tests that should make up the protocol for the physical evaluation of FMS patients, emphasizing their ease of use.
    Revista Brasileira de Reumatologia 04/2014; 54(2):117-123.
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    ABSTRACT: After many years without any substantial improvement in bicycle infrastructure in Curitiba, a 4-km Leisure Bicycle Lane was implemented in the central area of the city in 2011. The project was one of several that City Hall hurriedly implemented following pressure from bike activists. On the Sunday the project was launched, more than three thousand cyclists are estimated to have used the bicycle lane; of these, 300 cycled alongside the lane, outside it, against it. They made the front pages of newspapers, disrupted the sociotechnical framework of bicycle policy in the city and put bicycles on the political agenda of the municipal elections. This paper discusses why, in a city renowned worldwide for its public transportation system and for having more than a 100 km of bicycle lanes, a bicycle project failed after being sabotaged by cyclists and was definitively abandoned in February 2013. Based on interviews with key actors, including public officials, journalists, and bicycle activists, this paper concludes that the failed bicycle lane unveils the profound and urgent social and political dimensions embedded in what had been presented by municipal authorities as a neutral technical solution.
    Transport Policy 03/2014; 32:180–185.


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International Journal of Electrical Power & Energy Systems 06/2008;
Advances in Engineering Software 11/2008;

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See how the RG Scores of researchers from Pontifícia Universidade Católica do Paraná (PUC-PR) are distributed.