Kyoto University

Kyoto, Kyoto, Japan

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Graduate School of Medicine / Faculty of Medicine
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Graduate School of Agriculture / Faculty of Agriculture
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Graduate School of Informatics
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    ABSTRACT: We present a coupled lattice Boltzmann method (LBM) to solve a set of model equations for electrokinetic flows in micro-/nano-channels. The model consists of the Poisson equation for the electrical potential, the Nernst–Planck equation for the ion concentration, and the Navier–Stokes equation for the flows of the electrolyte solution. In the proposed LBM, the electrochemical migration and the convection of the electrolyte solution contributing to the ion flux are incorporated into the collision operator, which maintains the locality of the algorithm inherent to the original LBM. Furthermore, the Neumann-type boundary condition at the solid/liquid interface is then correctly imposed. In order to validate the present LBM, we consider an electro-osmotic flow in a slit between two charged infinite parallel plates, and the results of LBM computation are compared to the analytical solutions. Good agreement is obtained in the parameter range considered herein, including the case in which the nonlinearity of the Poisson equation due to the large potential variation manifests itself. We also apply the method to a two-dimensional problem of a finite-length microchannel with an entry and an exit. The steady state, as well as the transient behavior, of the electro-osmotic flow induced in the microchannel is investigated. It is shown that, although no external pressure difference is imposed, the presence of the entry and exit results in the occurrence of the local pressure gradient that causes a flow resistance reducing the magnitude of the electro-osmotic flow.
    Communications in Nonlinear Science and Numerical Simulation 04/2014; 19(10):3570–3590.
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    ABSTRACT: Nucleic acids, DNA and RNA, not only allow transfer and replication of densely coded genetic information, but also act as danger signals triggering innate immune response. Recent progress in the design and construction of nano-sized structures using DNA has opened a new field of nanotechnology. The unique properties of nano-sized DNA constructs can be exploited to develop programmable materials for efficient delivery of bioactive compounds. In this review, recent advances in DNA nanotechnology and its applications as delivery systems are summarized. In particular, we focus on the delivery of DNA containing unmethylated cytosine-phosphate-guanine (CpG) dinucleotide, or CpG motif, to immune cells expressing Toll-like receptor 9. Recent studies have shown that precisely designed DNA constructs, such as multi-branched DNA, polyhedral DNA, and DNA origami, can be used to enhance the biological activity of CpG DNA.
    European journal of pharmaceutical sciences: official journal of the European Federation for Pharmaceutical Sciences 03/2014;
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    ABSTRACT: In the field, plants are exposed to fluctuating light, where photosynthesis occurs under conditions far from a steady state. Excess energy dissipation associated with energy quenching of chlorophyll fluorescence (qE) functions as an efficient photo-protection mechanism in photosystem II. PsbS is an important regulator of qE, especially for the induction phase of qE. Beside the regulatory energy dissipation, some part of energy is lost through relaxation of excited chlorophyll molecules. To date, several models to quantify energy loss through these dissipative pathways in PSII have been proposed. In this short review, we compare and evaluate these models for PSII energy allocation when they are applied to non-steady state photosynthesis. As a case study, an investigation on energy allocation to qE-associated dissipation at PSII under non-steady state photosynthesis using PsbS-deficient rice transformants is introduced. Diurnal and seasonal changes in PSII energy allocation in rice under natural light are also presented. Future perspective of studies on PSII energy allocation is discussed.
    Plant Physiology and Biochemistry 03/2014;


  • Address
    36-1 Yoshida-Hommachi, Sakyo-ku , 606-8501 , Kyoto , Kyoto , Japan
  • Head of Institution
    Dr. Hiroshi Matsumoto
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Top publications last week by downloads

i-Perception. 01/2012; 3(2):112-40.
The Journal of Chemical Physics 07/2007; 126(24):244905.

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