[show abstract][hide abstract] ABSTRACT: This paper outlines the effect on micellar behavior of aqueous solutions of cationic surfactants viz. cetyltrimethylammonium bromide (CTAB) and cetyltrimethylammonium chloride (CTAC) upon addition of ionic liquid 3-methyl-1-pentylimidazolium hexafluorophosphate [C5mim][PF6]. Important physicochemical properties such as conductance, critical micelle concentration (cmc) and aggregation number (Nagg) are observed to change as [C5mim][PF6] is added to aqueous CTAB/CTAC. The conductivity/concentration data of aqueous solutions of CTAB/CTAC with [C5mim][PF6] were determined in the temperature range 298.15, 308.15, 318.15 K. These data were used to determine cmc as a function of temperature and concentration and to evaluate degree of ionization. Using temperature dependence of cmc, various thermodynamic parameters have been evaluated. Behavior of fluorescence probe, pyrene, confirms the interaction between [C5mim][PF6] and cationic micellar surface. Further, 1H NMR studies in micelle solutions containing [C5mim][PF6] have also been carried out in order to interpret the preferential solubilization site of [C5mim][PF6] on the studied micellar systems.
[show abstract][hide abstract] ABSTRACT: Traditional medicine is a blend of information gathered over generations from various communities and cultures. Pinus roxburghii Sargent (Pinaceae) commonly known as "chir pine" is widely used in traditional and folkloric systems of medicine. The all parts of the plant are believed to possess medicinal qualities in Ayurvedic and Unani systems of medicine. In these traditional systems of medicine, the plant is used to heal many diseases, including afflictions of the eyes, ears, throat, blood, and skin. The plant parts are rich in various bioactive compounds such as α-pinene, abietic acid, quercetin and xanthone. Resin acids and flavanoid form a major portion of these bioactive compounds. This review presents examples of traditional medicinal uses for P. roxburghii, and subsequently explores the current understanding of the chemical, pharmacological, and biochemical properties of the extracts and the main active constituents found in each tissue of the plant. Clinical trial information is also included where available. Careful evaluation of these data may be helpful for scientists and researchers to discover and evaluate the specific chemical entities responsible for the traditional medicinal uses of P. roxburghii.
Journal of integrative medicine. 11/2013; 11(6):371-6.
[show abstract][hide abstract] ABSTRACT: Searching for new anti-inflammatory agents, we have prepared a series of potential COX-2 inhibitors, 1-(4,6-dimethylpyrimidin-2-yl)-5-hydroxy-5-trifluoromethyl-Δ(2)-pyrazolines (3) and 1-(4,6-dimethylpyrimidin-2-yl)-3-trifluoromethylpyrazoles (4), by refluxing 2-hydrazino-4,6-dimethylpyrimidine (1) with a number of trifluoromethyl-β-diketones (2) in ethanol. Further dehydration of compounds (3) to the corresponding 1-(4,6-dimethylpyrimidin-2-yl)-5-trifluoromethylpyrazoles (5) was also achieved. Fifteen of these compounds were screened for their anti-inflammatory activity using the carrageenan-induced rat paw edema assay. While all the compounds exhibited significant anti-inflammatory activity (47-76%) as compared to indomethacin (78%), 3-trifluoromethylpyrazoles (4) were found to be the most effective agents (62-76%). To rationalize this anti-inflammatory activity, docking experiments molecular dynamics simulations were performed to study the ability of these compounds to bind into the active site of the COX-2 enzyme.
European journal of medicinal chemistry 10/2013; 70C:350-357.