Kitakyūshū, Fukuoka-ken, Japan

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Department of Chemical and Environmental Engineering
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Graduate School of Environmental Engineering
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    ABSTRACT: Rutile titania (TiO2) is an efficient photocatalyst for oxidizing water to O-2. The photocatalytic activity of particulate rutile for water oxidation was significantly improved by H-2 reduction at 700 degrees C, after calcination at 1100 degrees C. The improved activity was due to an increase in crystalline size during calcination, and an increase in conduction band electron concentration by the creation of oxygen vacancies. In contrast to the consideration that oxygen vacancy increases the recombination of electron and holes, the hydrogenated TiO2 exhibited high apparent quantum efficiency for O-2 evolution, 41% under irradiation at 365 nm. It was found that H-2 treatment improved the photocatalytic activity per unit of surface area not only for O-2 evolution but also for H-2 evolution and acetic acid decomposition. The effect of H-2 reduction treatment was obtained only if the rutile particle was previously calcined at temperatures higher than 1000 degrees C. This suggests that space charge layer in large crystalline particles is involved in the activation mechanism of hydrogenated rutile TiO2 particles.
    Applied Catalysis B Environmental 10/2014; s 158–159:202–208. DOI:10.1016/j.apcatb.2014.04.025
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    ABSTRACT: Highly efficient drug carriers targeting hepatocyte is needed for treatment for liver diseases such as liver cirrhosis and virus infections. Galactose or N-acetylgalactosamine is known to be recognized and incorporated into the cells through asialoglycoprotein receptor (ASGPR) that is exclusively expressed on hepatocyte and hepatoma. In this study, we synthesized a galactose-modified lipid with aromatic ring with click chemistry. To make a complex with DNA, termed 'lipoplex', we prepared a binary micelle composed of cationic lipid; dioleoyltrimethylammoniumpropane (DOTAP) and galactose-modified lipid (D/Gal). We prepared lipoplex from plasmid DNA (pDNA) and D/Gal and examined the cell specificity and transfection efficiency. The lipoplex was able to interact with ASGPR immobilized on gold substrate in the quartz-crystal microbalance (QCM) sensor cell. The lipoplex induced high gene expression to HepG2 cells, a human hepatocellular carcinoma cell line, but not to A549 cells, a human alveolar adenocarcinoma cell line. The treatment with asialofetuin, which is a ligand for ASGPR and would work as a competitive inhibitor, before addition of the lipoplexes decreased the expression to HepG2 cells. These results indicate that D/Gal lipoplex was incorporated into HepG2 cells preferentially through ASGPR and the uptake was caused by galactose specific receptor. This delivery system to hepatocytes may overcome the problems for gene therapy and be used for treatment of hepatitis and hepatic cirrhosis.
    Bioorganic & Medicinal Chemistry 10/2014; 22(19). DOI:10.1016/j.bmc.2014.08.012
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    ABSTRACT: A water soluble β-1,3-glucan schizophyllan (SPG) can be recognized by an immunocyte receptor called dectin-1. When we introduced naphthalene into the side chain of SPG (nSPG), it formed nanogel by physical cross-link and gained capability to ingest hydrophobic compounds such as doxorubicin. Our in vitro assay revealed that this nanogel can be used as specific delivery of anti-cancer drugs to immunocytes.
    Bioorganic & medicinal chemistry letters 03/2014; 24(8). DOI:10.1016/j.bmcl.2014.03.020


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    4-2-1 Kitagata, Kokuraminami Ward, 802-0841, Kitakyūshū, Fukuoka-ken, Japan
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Top publications last week by downloads

Chemistry Letters 06/2013; 42(6):595-597. DOI:10.1246/cl.130117

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