King's College London

London, London, United Kingdom

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School of Medicine
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Institute of Psychiatry
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Division of Imaging Sciences and Biomedical Engineering
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  • [Show abstract] [Hide abstract]
    ABSTRACT: This review focuses on the role of orientated cell division (OCD) in two aspects of epithelial growth, namely layer formation and growth in the epithelial plane. Epithelial stratification is invariably associated with fate asymmetric cell divisions. We discuss this through the example of epidermal stratification where cell division plane regulation facilitates concomitant thickening and cell differentiation. Embryonic neuroepithelia are considered as a special case of epithelial stratification. We highlight early ectodermal layer specification, which sets the epidermal versus neuronal fates, as well as later neurogenesis in vertebrates and mammals. We also discuss the heart epicardium as an example of coordinating OCDs with delamination and subsequent differentiation. Epithelial planar growth is examined both in the context of uniform growth, such as in Xenopus epiboly, the Drosophila wing disc and the mammalian intestinal crypt as well as in anisotropic growth, or elongation, such as Drosophila and vertebrate axial elongation and the mouse palate. Coupling between growth perpendicular to and within epithelial planes is recognised, but so are exceptions, as is the often passive role of spindle orientation sometimes hitherto considered to be an active driver of directional growth.
    Seminars in Cell and Developmental Biology 07/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: GPR55 belongs to the class A family of G-protein coupled receptor (GPCRs) and its activity is regulated by a range of synthetic and endogenous cannabinoids, and by lipid-derived ligands. Cannabinoids are known to be important in controlling appetite and metabolic balance, and it is now emerging that GPR55 may have a role to play in energy homeostasis through the regulation of food intake, fuel storage in adipocytes, gut motility and insulin secretion. This review summarises our current knowledge of expression and function of GPR55 in tissues involved in metabolic regulation, the signalling cascades through which GPR55 is reported to act to exert its effects, and it comments on the difficulties in reaching firm conclusions when using GPR55 ligands of poor specificity. Understanding the role of GPR55 in energy homeostasis may provide a novel target for therapeutic intervention in obesity and type 2 diabetes mellitus.
    Pharmacology & therapeutics. 06/2014;
  • The Journal of pediatrics. 05/2014;


  • Address
    Borough wing, Guy's Hospital, SE1 9RT, London, London, United Kingdom
  • Head of Institution
    Prof Reba rezavi
  • Website
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Top publications last week by downloads

International Journal of Nursing Studies 05/2007; 44(4):574-88.
International Journal of Nursing Studies 03/2004; 41(2):141-50.

Top Collaborating Institutions


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Rg score distribution

See how the RG Scores of researchers from King's College London are distributed.