Punjai Puliyampatti, India

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    ABSTRACT: MicroRNAs (miRNAs) are small endogenous genes regulators which regulate different processes underlying plant adaptation to abiotic stresses. To gain a deep understanding of role of miRNAs in plants, in the present study, we computationally analyzed different sorghum miRNAs in the drought-induced gene sequences. Homologous miRNA were identified using different plant miRNA databases. Using previously established genes databases, various targets of sorghum miRNAs were predicted viz: transcription factors, chaperonins, metabolic enzymes and other gene targets necessary for proper plant development. Analysis of cis-elements provides molecular evidence for the possible involvement of miRNAs in the process of abiotic stress tolerance in sorghum. Based on these results, it was suggested that miRNAs may play an important role in water stress tolerance.
    International Journal of Bioinformatics Research and Applications 06/2013; 9(4):349-364. DOI:10.1504/IJBRA.2013.054694
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    ABSTRACT: Ideally a drug should be administered in a form that it exerts its pharmacological action at the target site using the lowest concentration possible and without undesirable effects. Drug targeting is the approach which is followed for the purpose. Among different approaches preparation of synthetic glycosides of target drug and administering them orally is one of the most recent approaches. The drug glycoside on reaching colonic region releases the active drug through enzymatic action. This approach has been detailed with different successful examples. Synthetic drug-glycosides, besides being used as drug targeting agents, have been shown to exhibit varied biological activities such as antineoplastic, antidiabetic, antiinfllamatory etc., which have been reviewed. Synthetic approaches to O-, C-, N-, S glycosides have been discussed.
    Mini Reviews in Medicinal Chemistry 12/2012; 13(4). DOI:10.2174/1389557511313040010
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    ABSTRACT: We analyse the fusion cross-sections, calculated by using two different analytical parameterisations and compare them with the experimental data. Both the parameterisations are based on ion-ion potentials calculated within the framework of Skyrme energy density formalism. In the first case, the ion-ion potential (including the spin-density term) was parameterised and then, by adding the Coulomb potential, one could compute the fusion barrier analytically. In the second case, the calculated fusion barrier heights and positions were parameterised directly. Both of these (previously) reported parameterisations are used here to calculate the fusion barriers and fusion excitation functions for more than 50 reactions belonging to the s-d and f-shell nuclei. A detailed comparison of these parametrisations with the experimental and several other theoretical results shows that both of these parameterisations are able to reproduce the experimental data equally well. As the (second) direct parameterisation depends only on the charges and masses of colliding nuclei, it is very useful for predicting/ understanding the fusion process in low energy heavy-ion reactions.
    European Physical Journal A 04/2012; 8(1):103-114. DOI:10.1007/s100500070124


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    Punjai Puliyampatti, India
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Top publications last week by reads

Bioresource Technology 10/2007; 98(12):2243-57. DOI:10.1016/j.biortech.2005.12.006
32 Reads
Engineering in Life Sciences 04/2005; 5(2):158 - 162. DOI:10.1002/elsc.200420066
7 Reads

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