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Department of Biotechnology
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Department of Biochemistry
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Department of Physics
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  • [Show abstract] [Hide abstract]
    ABSTRACT: Aim The present study was undertaken to investigate the effect of Emilia sonchifolia on azaserine (O-diazoacetyl-L-serine) -induced pancreatic dysplasia in Wistar albino rats. Methods Administration of azaserine [30 mg/kg body weight intraperitoneal (i.p.) weekly for 1 month] to male Wistar albino rats resulted in pancreatic dysplasia, which was evident from the histopathological studies. Results A significant decrease of pancreatic and hepatic enzymatic antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and non-enzymatic antioxidants like vitamin C, glutathione (GSH) content, and a significant increase in pancreatic serum amylase and lipase, and hepatic marker enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were found. Treatment of rats with the n-hexane extract of Emilia sonchifolia for 16 weeks resulted in a concomitant reduction in pancreatic and hepatic damage. Conclusion The results suggest that Emilia sonchifolia can be used as a therapeutic agent against precancerous lesions which could prevent pancreatic dysplasia.
    Journal of Acute Medicine. 06/2014;
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    ABSTRACT: The present study deals with the removal of Cr (III) ion from aqueous solutions onto water washed raw leaves of Ricinus communis (RLRC) and microwave assisted zinc chloride activated Leaves of Ricinus communis (ZLRC). The adsorbent has been characterized with FTIR, SEM-EDAX and XRD studies. Adsorption experiments were carried out systematically by batch experiments to investigate the influence of different factors, such as contact time, initial concentration of metal ions, and pH of the solutions. The influence of other metal ions on the adsorption of Cr (III) ions was investigated. Adsorption capacity of the binary and ternary metal ions tested on RLRC and ZLRC was low as compared to single metal ions. The maximum adsorption of Cr (III) was observed at pH 7.05 for RLRC (47.37%) and ZLRC (58.97%). The adsorption of Cr (III) ions from aqueous solutions on RLRC and ZLRC could be favorably described by Langmuir isotherm, the adsorption kinetics was well fitted in Pseudo-second order and intra particle diffusion model. We investigate the recovery of the used adsorbent for its reusing is of great importance for environmental and economical reasons. i.e., RLRC and ZLRC will be recovered by desorption method by using proper desorption agent like H2O by batch mode study. Among RLRC and ZLRC, ZLRC shows most adsorption ability than RLRC. According to the experimental results, the adsorbent derived from this material is expected to be an economical product for metal ion remediation from water and waste water.
    Arabian Journal of Chemistry 03/2014;
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    ABSTRACT: Identification of miRNAs encoded by sugarcane streak mosaic virus and understanding their host target genes might be used as a new strategy to study viral pathogenesis and controlling mosaic disease in sugarcane. Plants have developed several defense mechanisms to cope with various pathogens (bacteria, fungi, virus, and phytoplasma). Among these, RNA interference (RNAi)-mediated defense against viral infection was found to be a major innate immune response. As a counter attack strategy against the host defense, viruses produce suppressors of host RNAi pathway. MicroRNAs (miRNAs) are an abundant class of short (~18-22 nucleotide) non-coding single-stranded RNAs involved in RNAi pathway leading to post-transcriptional regulation of gene expression. Sugarcane streak mosaic virus (SCSMV) is a distinct strain of Potyviridae family which has a single-stranded positive-sense RNA genome causing mosaic disease in sugarcane. In this study, we computationally predicted and experimentally validated the miRNA encoded by the SCSMV genome with detection efficiency of 99.9 % in stem-loop RT-qPCR and predicted their potential gene targets in sugarcane. These sugarcane target genes considerably broaden future investigation of the SCSMV-encoded miRNA function during viral pathogenesis and might be applied as a new strategy for controlling mosaic disease in sugarcane.
    Plant Cell Reports 10/2013;


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    Coimbatore, India
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Top publications last week by downloads

Indian Journal of Pharmaceutical Education and Research. 01/2011;
Journal of Pharmacy Research. 01/2011;

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