Departments View all

Total Impact Points
Total Impact Points

Recent Publications View all

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Niosomes are self assembled vesicles composed primarily of synthetic surfactants and cholesterol. They are analogous in structure to the more widely studied liposomes formed from biologically derived phospholipids. Niosomes represent an emerging class of novel vesicular systems. Niosome formation requires the presence of a particular class of amphiphile and aqueous solvent. In recent years a comprehensive research carried over niosome as a drug carrier. Various drugs are enlisted and tried in niosome surfactant vesicles. Niosomes proved to be a promising drug carrier and has potential to reduce the side effects of drugs and increased therapeutic effectiveness in various diseases.
    International Journal of Pharmaceutical Sciences and Research 08/2015; 1-Vol.(-9):1-8. DOI:10.13040/IJPSR.0975-8232.1(9-S).1-8
  • [Show abstract] [Hide abstract]
    ABSTRACT: Organophosphates (OPs) pesticides are among the most toxic synthetic chemicals purposefully added in the environment. The common use of OP insecticides in public health and agriculture results in an environmental pollution and a number of acute and chronic poisoning events. Present study was aimed to evaluate the potential of monocrotophos and quinalphos to effect the redox status and glutathione (GSH) homeostasis in rat tissues and find out whether antioxidant vitamins have some protection on the pesticide-induced alterations. The results showed that these pesticides alone or in combination, caused decrease in the levels of GSH and the corresponding increase in the levels of GSSG, decreasing the GSH/GSSG ratio. The results also showed that NADPH/NADP(+) and NADH/NAD(+) ratios were decreased in the liver and brain of rats on exposure with mococrotophos, quinalphos, and their mixture. These pesticides, alone or in combination, caused alterations in the activities of GSH reductase and glucose-6-phosphate dehydrogenase in the rat tissues. However, the expression of the GSH recycling enzymes did not show significant alterations as compared to control. From the results, it can be concluded that these pesticides generate oxidative stress but their effects were not synergistic when given together and prior feeding of antioxidant vitamins tend to reduce the toxicities of these pesticides. © 2013 Wiley Periodicals, Inc. Environ Toxicol, 2013.
    Environmental Toxicology 04/2015; 30(4). DOI:10.1002/tox.21924
  • [Show abstract] [Hide abstract]
    ABSTRACT: Experimental studies have shown that sulphur-containing antioxidants have beneficial effects against the detrimental properties of Pb. In the present study, we investigated the therapeutic potential of combined administration of N-acetyl cysteine (NAC; 50 mg/kg p.o.) and selenium (Se; 0.5 mg/kg p.o.) against lead acetate intoxication (Pb; 0.2% in water ad libitum) in a male rat model for 12 wk. The exposure of rats to lead acetate produced significant (P < 0.05) alterations in cytochrome P450 (CYP) activity, microsomal lipid peroxidation, reduced glutathione, and proteins. In addition, significant elevation in liver markers transaminases, triglycerides, cholesterol, and bilirubin as well as a decline in albumin were also compared with the experimental control rats. Combined treatment of lead-exposed animals with NAC and Se showed marked improvement of the biochemical, molecular, and histopathological findings. These experimental results strongly indicate the protective effect of NAC alone with Se against toxic effects of lead on liver tissue.
    Journal of Environmental Pathology Toxicology and Oncology 01/2015; 34(1):23-34. DOI:10.1615/JEnvironPatholToxicolOncol.2015012006


  • Address
    Gwalior, India
Information provided on this web page is aggregated encyclopedic and bibliographical information relating to the named institution. Information provided is not approved by the institution itself. The institution’s logo (and/or other graphical identification, such as a coat of arms) is used only to identify the institution in a nominal way. Under certain jurisdictions it may be property of the institution.

259 Members View all

View all

Top publications last week by reads

Phase Transitions 12/2009; 82(12-12):850-865. DOI:10.1080/01411590903326628
39 Reads
Current Medicinal Chemistry 08/2010; 17(22):2419-30. DOI:10.2174/092986710791698495
35 Reads

Top Collaborating Institutions


This map visualizes which other institutions researchers from Jiwaji University have collaborated with.

Rg score distribution

See how the RG Scores of researchers from Jiwaji University are distributed.