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Center for Nursing Care Research
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School of Chemical Engineering
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    ABSTRACT: The application of gold nanoparticles (AuNPs) in nanophotothermolysis as a great photosensitizer is expanding, and this subject is a challenging area for cancer therapy. Recent technological advances in nanoscale manufacturing and synthesis promise the development of highly beneficial and innovative methods for the targeting of cancer. However, there is an obstacle to conducting effective laser-based nanosurgery because AuNPs are activated by visible or near infrared wavelengths, and the penetration of a laser beam inside the body is limited by some absorbents, such as melanin, water, and blood molecules. Considering everything stated above, we have suggested the application of a folate-conjugated AuNP as an effective agent for targeted nanophotothermolysis and the application of an optical fiber to transport the laser light from the source to the target tissue inside the body. Thus, a new method of nanosurgery in which a surgeon is able to perform surgery at the cellular or even at the subcellular level may be possible.
    Lasers in Medical Science 03/2014; 29(2):847-853.
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    ABSTRACT: Background/Purpose: Tuberculosis is a crucial health problem. Prevention of the disease requires rapid diagnosis. Rapid liquid culture systems, nucleic acid amplification tests and high-performance liquid chromatography (HPLC) are among the rapid tests used for detecting Mycobacterium species. However, these tests are expensive and require extensive equipment and expertise which is hardly affordable in resource-poor countries. Although direct microscopy is performed routinely as an initial step for detection of the bacteria, it is not sufficiently sensitive. As a result, we thought of establishing a low-cost immunological test that can potentially replace direct microscopy with higher sensitivity and specificity. Method: The assay is based on pre-incubation of biotinylated rabbit antibody against Antigen 60 with a solution containing Bacillus Calmette-Guerin (BCG) or Mycobacterium tuberculosis (MTB) followed by incubation with streptavidin-alkaline phosphatase conjugate. The test is devised in ELISA and non-ELISA formats so that it may not require extensive facilities and expertise. Results: The ELISA format has shown a 100-fold improvement in lower detection limit of BCG comparing to direct microscopy. In non-ELISA formats, this amount was 2 and 16-fold improvement for cartridge assay and microfuge tube assay, respectively. Conclusion: In conclusion, we successfully detected BCG and Mycobacterium tuberculosis in solution using the new immunological method. Our results are very promising and the new immunological method could potentially replace direct microscopy with higher sensitivity and specificity.
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 01/2014;
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    ABSTRACT: Introduction Electrical injury is relatively uncommon but it is a devastating form of thermal injury. The aim of this study is to analyze specific aspects of electrical injuries, especially the effect of current pathways on morbidity and mortality. Method This descriptive-analytical study was performed on patients with electrical burns who were admitted to the Shahid Motahary Burn Center from April 2010 to March 2012. Demographic and clinical data including gender, age, length of hospital stay, total body surface area (TBSA), grading of burn, electrical voltage, inlet electrical mark, outflow electrical mark, current pathway, surgical procedures, and place of electrical burn have been gathered from medical records. The site of inlet and outlet of current on the body is divided into six groups: Rt (right) upper limb, Lt (left) upper limb, Rt lower limb, Lt lower limb, head and neck, and trunk. According to these sites, the current pathway is defined to seven groups. Data were analyzed with SPSS software, version 20. Results From 287 patients, 283 were men and 4 were women. The mean age was 30 ± 12 years (range 1–71) and mean TBSA was 13.56 ± 12.97% (range 1–100). There were 233 patients (81.2%) with passage of the electrical current through the body and 54 patients (18.8%) with flash burns. A total of 859 surgical procedures were performed on 232 patients. One hundred and eighteen amputations were performed in 83 patients. The most common inlet electrical marks were in Rt upper limb and the most common outlet electrical marks were in Lt lower limbs, and consequently, the most common pathway was upper limb to lower limb. Conclusions Electrical injuries are mainly occupation-related injuries and in this research majority of injuries occurred outdoor by high voltage cables in young men. Thus the government should consider a distinct strategy for this group. Also it is observed that there were no significant differences in mortality and complications such as amputation between different pathways.
    Burns. 01/2014;


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Journal of North Khorasan University of Medical Sciences. 12/2013; 5(4):849-858.
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