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Center for Nursing Care Research
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School of Chemical Engineering
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    ABSTRACT: Background/Purpose: Tuberculosis is a crucial health problem. Prevention of the disease requires rapid diagnosis. Rapid liquid culture systems, nucleic acid amplification tests and high-performance liquid chromatography (HPLC) are among the rapid tests used for detecting Mycobacterium species. However, these tests are expensive and require extensive equipment and expertise which is hardly affordable in resource-poor countries. Although direct microscopy is performed routinely as an initial step for detection of the bacteria, it is not sufficiently sensitive. As a result, we thought of establishing a low-cost immunological test that can potentially replace direct microscopy with higher sensitivity and specificity. Method: The assay is based on pre-incubation of biotinylated rabbit antibody against Antigen 60 with a solution containing Bacillus Calmette-Guerin (BCG) or Mycobacterium tuberculosis (MTB) followed by incubation with streptavidin-alkaline phosphatase conjugate. The test is devised in ELISA and non-ELISA formats so that it may not require extensive facilities and expertise. Results: The ELISA format has shown a 100-fold improvement in lower detection limit of BCG comparing to direct microscopy. In non-ELISA formats, this amount was 2 and 16-fold improvement for cartridge assay and microfuge tube assay, respectively. Conclusion: In conclusion, we successfully detected BCG and Mycobacterium tuberculosis in solution using the new immunological method. Our results are very promising and the new immunological method could potentially replace direct microscopy with higher sensitivity and specificity.
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 04/2014;
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    ABSTRACT: The application of gold nanoparticles (AuNPs) in nanophotothermolysis as a great photosensitizer is expanding, and this subject is a challenging area for cancer therapy. Recent technological advances in nanoscale manufacturing and synthesis promise the development of highly beneficial and innovative methods for the targeting of cancer. However, there is an obstacle to conducting effective laser-based nanosurgery because AuNPs are activated by visible or near infrared wavelengths, and the penetration of a laser beam inside the body is limited by some absorbents, such as melanin, water, and blood molecules. Considering everything stated above, we have suggested the application of a folate-conjugated AuNP as an effective agent for targeted nanophotothermolysis and the application of an optical fiber to transport the laser light from the source to the target tissue inside the body. Thus, a new method of nanosurgery in which a surgeon is able to perform surgery at the cellular or even at the subcellular level may be possible.
    Lasers in Medical Science 03/2014; 29(2):847-853.
  • Journal of Emergency Medicine 02/2014; 46(2):279–280.


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Top publications last week by downloads

Scientific Journal of Kurdistan University of Medical Sciences 09/2012; 2(17):44-52.
Social welfare. 04/2011; 11(1):107-127.

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