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    ABSTRACT: Corbard & Thompson analyzed quantitatively the strong radial differential rotation that exists in a thin layer near the solar surface. We investigate the role of this radial shear in driving a flux transport dynamo operating with such a rotation profile. We show that despite being strong, near-surface radial shear effectively contributes only ∼1 kG (∼30% of the total) to the toroidal fields produced there unless an abnormally high, surface a-effect is included. While 3 kG spot formation from ∼1–2 kG toroidal fields by convective collapse cannot be ruled out, the evolutionary pattern of these model fields indicates that the polarities of spots formed from the near-surface toroidal field would violate the observed polarity relationship with polar fields. This supports previous results that large-scale solar dynamos generate intense toroidal fields in the tachocline, from which buoyant magnetic loops rise to the photosphere to produce spots. Polar fields generated in flux transport models are commonly much higher than observed. We show here that by adding enhanced diffusion in the supergranulation layer (originally proposed by Leighton), near-surface toroidal fields undergo large diffusive decay preventing spot formation from them, as well as reducing polar fields closer to the observed values. However, the weaker polar fields lead to the regeneration of a toroidal field of less than ∼10 kG at the convection zone base, too weak to produce spots that emerge in low latitudes, unless an additional poloidal field is produced at the tachocline. This is achieved by a tachocline a-effect, previously shown to be necessary for coupling the north and south hemispheres to ensure toroidal and poloidal fields that are antisymmetric about the equator.
    The Astrophysical Journal 02/2016; 575(1):41-45. DOI:10.1086/342555
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    ABSTRACT: ‘Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance’, published in Philosophical Transactions B in 1956 by Peter Medawar and his colleagues, PhD graduate Leslie Brent and postdoctoral fellow Rupert Billingham, is a full description of the concept of acquired transplantation tolerance. Their 1953 Nature paper (Billingham RE et al. 1953 Nature 172, 603–606. (doi:10.1038/172603a0)) had provided initial evidence with experimental results from a small number of neonatal mice, with mention of similar findings in chicks. The Philosophical Transactions B 1956 paper is clothed with an astonishing amount of further experimental detail. It is written in Peter Medawar's landmark style: witty, perceptive and full of images that can be recalled even when details of the supporting information have faded. Those images are provided not just by a series of 20 colour plates showing skin graft recipient mice, rats, rabbits, chickens and duck, bearing fur or plumage of donor origin, but by his choice of metaphor, simile and analogy to express the questions being addressed and the interpretation of their results, along with those of relevant published data and his prescient ideas of what the results might portend. This work influenced both immunology researchers and clinicians and helped to lay the foundations for successful transplantation programmes. It led to the award of a Nobel prize in 1960 to Medawar, and subsequently to several scientists who advanced these areas. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.
    Philosophical Transactions of The Royal Society B Biological Sciences 04/2015; 370(1666). DOI:10.1098/rstb.2014.0382
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    ABSTRACT: The nature of statistics has changed over time. It was originally concerned with descriptive 'matters of state'-with summarizing population numbers, economic strength and social conditions. But during the course of the twentieth century its aim broadened to include inference-how to use data to shed light on underlying mechanisms, about what might happen in the future, about what would happen if certain actions were taken. Central to this development was Ronald Fisher. Over the course of his life he was responsible for many of the major conceptual advances in statistics. This is particularly illustrated by his 1922 paper, in which he introduced many of the concepts which remain fundamental to our understanding of how to extract meaning from data, right to the present day. It is no exaggeration to say that Fisher's work, as illustrated by the ideas he described and developed in this paper, underlies all modern science, and much more besides. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.
    Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences 04/2015; 373(2039). DOI:10.1098/rsta.2014.0252


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Top publications last week by downloads

FEBS letters 12/2010; 584(24):4838-44. DOI:10.1016/j.febslet.2010.09.003
Kidney International 11/1997; 52(5):1313-20. DOI:10.1038/ki.1997.456

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