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ABSTRACT: In septic shock, high adrenergic stress is associated with cardiovascular and systemic adverse effects, which can negatively affect the results. Beta-adrenergic receptor block has been shown to be effective in controlling the disproportionate increase in heart rate, maintaining a favorable hemodynamic profile and apparently improving the efficiency of the cardiovascular system in order to maintain tissue perfusion. They have also been shown to modulate favorably catecholamine-induced immunosuppression and to decrease insulin resistance, protein catabolism, and proinflammatory cytokine expression associated with cardiovascular dysfunction. Selective beta-1 blockers appear to provide better results than non-selective blockers, even suggesting a positive impact on mortality. Future clinical trials are still needed to confirm these findings and define the scope of their benefits.Revista espanola de anestesiologia y reanimacion 08/2014; 62(2). DOI:10.1016/j.redar.2014.07.003
- Endocrinología y Nutrición 04/2014; DOI:10.1016/j.endonu.2013.10.010
- Endocrinología y Nutrición 01/2014; 61(4). DOI:10.1016/j.endoen.2014.03.006
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