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Department of Pharmaceutical Sciences
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Department of Bio & Nano Technology
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    ABSTRACT: ______________________________________________________________________________ ABSTRACT The thermal behavior of pristine and γ-irradiated CR-39 polymer (upto a maximum dose of 1800 kGy) has been studied using Thermogrametric analysis. The changes in degradation activation energy, frequency factor, entropy of activation, free energy of decomposition and rate coefficient have been analyzed as a consequence of γ-irradiation. The results clearly indicate the lowering of thermal stability of CR-39 as an effect of γ-irradiation. Such a reduction in thermal stability has been tried to be correlated with the induced structural changes as revealed by FTIR spectroscopy.
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    ABSTRACT: Acute and chronic effects of ellagic acid on pentylenetetrazole and picrotoxin-induced convulsions were evaluated in Swiss young male albino mice. Ellagic acid (20 and 40 mg/kg, p.o.) and diazepam (0.5 mg/kg, i.p.) per se were administered once for acute treatment and 14 successive days for chronic treatment. Pentylenetetrazole (80 mg/kg, i.p.) induced tonic and clonic convulsions, but picrotoxin (6 mg/kg, i.p.) induced only tonic convulsions. Acute administration of higher dose (40 mg/kg) and chronic administration of both the doses of ellagic acid significantly delayed onset of convulsions, decreased duration of clonic and tonic convulsions; and reduced mortality as compared to pentylenetetrazole and picrotoxin treated control. Ellagic acid also reversed pentylenetetrazole and picrotoxin-induced decrease in brain GABA levels. Acute and chronic administration of diazepam showed significant anticonvulsant activity and increased brain GABA levels. Thus, ellagic acid showed significant antiepileptic activity in mice probably through increase of GABAergic transmission in brain.
    Journal of Functional Foods 09/2014; 10:364–369. DOI:10.1016/j.jff.2014.07.011
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    ABSTRACT: Trans fatty acids have the presence of one or more double bonds in the trans configuration instead of the usual cis configuration. They are desired by Vanaspati industry as they impart firmness to margarines and plasticity as well as emulsion stability to shortenings. Research has proved the direct connection of trans fatty acids with cardiovascular diseases, breast cancer, shortening of pregnancy period, risks of preeclampsia, disorders of nervous system and vision in infants, colon cancer, diabetes, obesity and allergy. In light of these new findings trans fatty intake should be zero and new technology of hydrogenation of oils is to be developed which produce zero trans fatty acids at the same time preserve the desirable properties contributed by trans fatty acids to the hydrogenated oils. Presently in India there is no system to monitor and regulate the amount of trans fats in processed foods and hence a stringent food law is immediately required.
    Journal of Food Science and Technology -Mysore- 06/2014; 48(5):534-41. DOI:10.1007/s13197-010-0225-8


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IEEE Fourth International Conference on Advanced Computing & Communication Technologies, Rohtak, Haryana, India; 02/2014
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