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    ABSTRACT: Metastatic renal cell carcinoma is potentially a lethal disease with in some cases aggressive behavior. The given fact that the patterns of metastases from RCC are not clearly identified, which may involve some rare metastatic locations. We present a case of 58 years old male presented with painless left scrotal mass, which was discovered to be an intrascrotal metastases appeared 3 years after nephrectomy for ipsilateral renal cell carcinoma. We believe that the rarity of the metastatic site and the intriguing possible mechanism of spread make an interesting case for clinicians and could add more follow-up measures for patients treated from renal cell carcinoma.
    Urology Case Reports 10/2015; DOI:10.1016/j.eucr.2015.09.010
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    ABSTRACT: DNA testing is an established part of the investigation and prosecution of sexual assault. The primary purpose of DNA evidence is to identify a suspect and/or to demonstrate sexual contact. However, due to highly uneven proportions of female and male DNA in typical stains, routine autosomal analysis often fails to detect the DNA of the assailant. To evaluate the forensic efficiency of the combined application of autosomal and Y-chromosomal short tandem repeat (STR) markers, we present a large retrospective casework study of probative evidence collected in sexual-assault cases. We investigated up to 39 STR markers by testing combinations of the 16-locus NGMSElect kit with both the 23-locus PowerPlex Y23 and the 17-locus Yfiler kit. Using this dual approach we analyzed DNA extracts from 2077 biological stains collected in 287 cases over 30 months. To assess the outcome of the combined approach in comparison to stand-alone autosomal analysis we evaluated informative DNA profiles. Our investigation revealed that Y-STR analysis added up to 21% additional, highly informative (complete, single-source) profiles to the set of reportable autosomal STR profiles for typical stains collected in sexual-assault cases. Detection of multiple male contributors was approximately three times more likely with Y-chromosomal profiling than with autosomal STR profiling. In summary, 1/10 cases would have remained inconclusive (and could have been dismissed) if Y-STR analysis had been omitted from DNA profiling in sexual-assault cases. Copyright © 2015 Z. Published by Elsevier Ireland Ltd.. All rights reserved.
    Forensic Science International: Genetics 08/2015; 19:238-242. DOI:10.1016/j.fsigen.2015.08.002
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    03/2015; 22(4). DOI:10.1016/j.ebiom.2015.03.022


  • Address
    Chariteplatz 1, 10117, Berlin, Germany
  • Head of Institution
    Professor Karl Max Einhäupl
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Top publications last week by reads

ISMRM 2015, Toronto; 06/2015
416 Reads
The American Journal of Human Genetics 09/2006; 79(2):402-8. DOI:10.1086/506332
198 Reads

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See how the RG Scores of researchers from Charité Universitätsmedizin Berlin are distributed.