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Chemical Laboratory (CLRI)
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16
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Chemical Engineering Division (CLRI)
173
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Publication History View all

  • [Show abstract] [Hide abstract]
    ABSTRACT: Here we report the preparation of collagen-poly(dialdehyde) guar gum based hybrid functionalized scaffolds covalently immobilized with platelet derived growth factor - BB for tissue engineering applications. Poly(dialdehyde) guar gum was synthesized from selective oxidation of guar gum using sodium periodate. The synthesized poly(dialdehyde) guar gum not only promotes crosslinking of collagen but also immobilizes the platelet derived growth factor through imine bonds. The covalent crosslinking formed in collagen improves thermal, swelling and biodegradation properties of the hybrid scaffolds. The prepared hybrid scaffolds show 3D interconnected honeycomb porous structure when viewed under a microscope. The release of immobilized platelet derived growth factor was seen up to 13th day of incubation thereby proving its sustained delivery. The developed hybrid scaffold leads to a quantum increase in NIH 3T3 fibroblast cell density and proliferation thereby demonstrating its potential for tissue engineering applications.
    Carbohydrate Polymers 12/2014; 114:399–406. DOI:10.1016/j.carbpol.2014.08.045
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    ABSTRACT: This study highlights the role of marine microbial biosurfactants on solubilization/removal of crude-oil contamination from four different soils in an aqueous phase. Soil of four different types, viz., sandy, fine sand soil, clay, and clay loam, were collected and saturated with crude oil. Marine isolate MTCC 5514 (Bacillus licheniformis) was chosen for the study and comparisons were made with synthetic surfactants and commercially available biosurfactant. In-situ studies were carried out with different percentages of crude oil to assess the growth and the percentage removal of oil. For ex-situ studies, soils were pre-saturated with crude oil and then treated with the chosen biosurfactant at a 10% concentration level using flask and column methods. After time intervals of 30–120 min, samples were collected and then subjected to extraction with hexane and the percentage removal was calculated. Results revealed, at 2% concentration of crude oil, that complete solubilization was achieved. With regard to ex-situ studies, clay soil absorbed the maximum percentage of oil compared to other soil types, and with regard to the removal, all the synthetic surfactants showed <60% removal irrespective of soil type. In the case of biosurfactants even at 10% concentration, >85% removal was achieved.
    International Biodeterioration & Biodegradation 10/2014; 94:24–30. DOI:10.1016/j.ibiod.2014.04.028
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    ABSTRACT: A new series of bis- and tris-spirooxindole derivatives have been synthesized by controlling the molar equivalent of in situ generated azomethine ylides in [3+2]-cycloaddition reactions with dipolarophiles. The structural elucidation on the basis of IR, 1H NMR, 13C NMR, and mass spectral data of these compounds established the highly chemoselective and regioselective formation of spirooxindole derivatives. Single crystal X-ray analysis of compound 4g and 2D NMR analysis of compound 5a confirmed the structures of bis- and tris-spirooxindole derivatives.
    Tetrahedron Letters 09/2014; 45(40). DOI:10.1002/chin.201440122

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    Chennai, India
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Top publications last week by downloads

 
Biochimica et Biophysica Acta 01/2014; 1840:1913-1922. DOI:10.1016/j.bbagen.2014.01.016
17 Downloads
 
Journal of Biomedical Materials Research Part B Applied Biomaterials 05/2013; 101B(4). DOI:10.1002/jbm.b.32856
16 Downloads

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