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Diagram of meiosis and mitosis (normal cell division) with one pair of homologous chromosomes. Adapted from Alberts et al., 1994. 

Diagram of meiosis and mitosis (normal cell division) with one pair of homologous chromosomes. Adapted from Alberts et al., 1994. 

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Aneuploidien oder numerische Chromosomenaberrationen sind charakterisiert durch eine Abweichung des normalen diploiden Chromosomensatzes in somatische Zellen oder des haploiden Chromosomensatzes in Keimzellen. Aneuploidien zählen zu den häufigsten chromosomalen Aberrationen in der menschlichen Population; etwa 50 % aller spontanen Aborte sind aneup...

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Context 1
... the end of telophase. At cytokinesis the formation of the nuclear envelope is completed and the contractile ring forms a cleavage furrow at the midbody, the region of microtubule overlap. The cytoplasm is divided at the site of the cleavage furrow, resulting in two daughter cells. Thus each daughter cell receives an identical set of chromosomes ( Fig. ...
Context 2
... consists of two successive cell divisions (Fig. 3). The first meiotic division (meiosis I; MMI) reduces the number of chromosomes from diploid (2n) to haploid (n) chromosome sets and is called reduction division. The second meiotic division (meiosis II; MMII) distributes the chromatids evenly to the two daughter cells. In preparation of the first meiotic division, homologous ...
Context 3
... II, the chromosomes align on the spindle with microtubules from opposite poles of the spindle attached to the kinetochores of sister chromatids. The link between the centromeres of sister chromatids is broken at anaphase II, and sister chromatids segregate to opposite poles. Cytokinesis then follows, giving rises to haploid daughter cells (Fig. 3). At fertilization, the diploid state is restored by fusion of sperm and egg to form a zygote. The genetic constitution of the zygote will be different from that of either parent because of the recombinational events, which occurred during meiosis. In mammals, the sex of the new individual, which develops from the zygote, is determined ...

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